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PMID: 3877309 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Functional mapping of the human cerebellum with positron emission tomography.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 21 ·1985-11-00 ·Pages 7462-6

Fox PT, Raichle ME, Thach WT

Abstract

Alterations of local neuronal activity induced within the human cerebellum by tactile stimulation and voluntary movement were mapped with positron emission tomographic measurements of brain blood flow. Finger movements produced bilateral, parasagittal blood-flow increases in anterior, superior hemispheric cortex of the cerebellum. Responses to tactile finger stimulation were coextensive with responses to voluntary finger movements but were less intense. Saccadic eye movements produced midline blood-flow increases in the posterior vermis of the cerebellum. Positron emission tomography now permits investigation of functional-anatomical relations within the human cerebellum.

MeSH Terms
Brain Mapping Cerebellum/anatomy & histology,physiology Cerebrovascular Circulation Dominance, Cerebral Eye Movements Fingers Humans Movement Tomography, Emission-Computed Touch
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fox P T
Raichle M E
Thach W T
References (16)
16 references, click to expand
  1. Eye movements evoked by cerebellar stimulation in the alert monkey.
    J Neurophysiol. 1973 Nov;36(6):1004-22 PMID: 4202613
  2. The cerebellum of the cat and the monkey.
    J Comp Neurol. 1953 Aug;99(1):135-99 PMID: 13084788
  3. Magnetic phenomena of the central nervous system.
    Annu Rev Biophys Bioeng. 1978;7:167-88 PMID: 352239
  4. Quantitation in positron emission computed tomography: 2. Effects of inaccurate attenuation correction.
    J Comput Assist Tomogr. 1979 Dec;3(6):804-14 PMID: 315970
  5. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values.
    J Comput Assist Tomogr. 1980 Dec;4(6):727-36 PMID: 6971299
  6. Symposium summary. Neuronal activity and energy metabolism.
    Fed Proc. 1981 Jul;40(9):2353-62 PMID: 6265285
  7. Scope of a technique for electrical stimulation of human brain, spinal cord, and muscle.
    Lancet. 1982 Sep 11;2(8298):597-600 PMID: 6125739
  8. Positron emission tomography.
    Annu Rev Neurosci. 1983;6:249-67 PMID: 6340590
  9. Brain blood flow measured with intravenous H2(15)O. I. Theory and error analysis.
    J Nucl Med. 1983 Sep;24(9):782-9 PMID: 6604139
  10. Brain blood flow measured with intravenous H2(15)O. II. Implementation and validation.
    J Nucl Med. 1983 Sep;24(9):790-8 PMID: 6604140
  11. Stimulus rate dependence of regional cerebral blood flow in human striate cortex, demonstrated by positron emission tomography.
    J Neurophysiol. 1984 May;51(5):1109-20 PMID: 6610024
  12. A stereotactic method of anatomical localization for positron emission tomography.
    J Comput Assist Tomogr. 1985 Jan-Feb;9(1):141-53 PMID: 3881487
  13. The role of cerebral cortex in the generation of voluntary saccades: a positron emission tomographic study.
    J Neurophysiol. 1985 Aug;54(2):348-69 PMID: 3875696
  14. Cerebrocerebellar relationships in the monkey.
    J Neurophysiol. 1952 Jan;15(1):27-40 PMID: 14908622
  15. Cerebro-cerebellar projections and the somatotopic localization of motor function in the cerebellum.
    Res Publ Assoc Res Nerv Ment Dis. 1952;30:299-316 PMID: 12983678
  16. Functional linkage between the electrical activity in the vermal cerebellar cortex and saccadic eye movements.
    Exp Brain Res. 1977 Aug 8;29(1):1-14 PMID: 408163
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.21.7462
Published
1985-11-00
Pages
7462-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC391365
Subset
IM
Grants
NHLBI NIH HHS · HL13851 · United States
NINDS NIH HHS · NS06833 · United States
NINDS NIH HHS · NS14834 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.21.7462 PMC Full Text View journal details
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