DR and non-DR Ia allotypes are associated with susceptibility to coeliac disease.
We have studied the frequency of HLA-DR, -MT, and -MB antigens in adult patients with coeliac disease and in a group of healthy controls, evaluating the strength of the observed associations by measuring the aetiologic fractions. Among the antigens significantly associated with coeliac disease, MB2 (DQw2) showed an aetiologic fraction higher than those of DR3 and DR7. Our results suggest that MB2, as associated more frequently than other specificities with a hypothetical disease predisposing gene, may play a role in the pathogenesis of coeliac disease. The significant association of DR3 and DR7 with coeliac disease may be ascribed to linkage disequilibrium of these antigens with MB2.
19 references, click to expand
-
Genetic basis of gluten-sentitive enteropathy.Gastroenterology. 1978 Aug;75(2):230-5 PMID: 307512
-
B-lymphocyte alloantigens associated with systemic lupus erythematosus.N Engl J Med. 1978 Sep 7;299(10):515-8 PMID: 308181
-
Genetic differences between primary and secondary sicca syndrome.N Engl J Med. 1979 Oct 4;301(14):761-3 PMID: 314586
-
Identification of an HLA-DR-associated system of B-cell alloantigens.Transplant Proc. 1979 Dec;11(4):1757-60 PMID: 93800
-
Association of the B-cell alloantigen MBI with HLA-DRw1 and DRw2.Transplant Proc. 1980 Mar;12(1):138-40 PMID: 6154352
-
Adult celiac disease associated with HLA-DRw3 and -DRw7.Tissue Antigens. 1980 Mar;15(3):231-8 PMID: 6936866
-
Histocompatibility determinants in Israeli Jewish patients with coeliac disease: population and family study.Tissue Antigens. 1981 Mar;17(3):313-22 PMID: 6947507
-
Association between Takayasu's arteritis and a B-cell alloantigen in North Americans.N Engl J Med. 1982 Feb 25;306(8):464-5 PMID: 6977091
-
Immunogenetic aspects of the relationship between HLA-DR and the MB and MT system.Transplant Proc. 1981 Dec;13(4):1804-7 PMID: 6977217
-
Measuring the strength of associations between HLA antigens and diseases.Tissue Antigens. 1981 Nov;18(5):356-63 PMID: 7344182
-
The epidemiologic approach to studies of association between HLA and disease. II. Estimation of absolute risks, etiologic and preventive fraction.Tissue Antigens. 1982 Apr;19(4):259-68 PMID: 7101270
-
Immunoglobulin allotype markers in gluten-sensitive enteropathy.Lancet. 1983 Apr 30;1(8331):952-3 PMID: 6132268
-
HLA-DR3 and DR7 in coeliac disease: immunogenetic and clinical aspects.Gut. 1983 Aug;24(8):706-12 PMID: 6603391
-
Evidence that celiac disease is primarily associated with a DC locus allelic specificity.Clin Immunol Immunopathol. 1983 Sep;28(3):395-404 PMID: 6192959
-
HLA-DR typing in coeliac disease: evidence for genetic heterogeneity.Br Med J (Clin Res Ed). 1984 Dec 8;289(6458):1571-3 PMID: 6439322
-
HL-A antigens and disease. Statistical and genetical considerations.Tissue Antigens. 1974;4(2):95-105 PMID: 4134648
-
HLA-DW3 associated with coeliac disease.Lancet. 1976 Mar 6;1(7958):506-8 PMID: 55781
-
Microdroplet testing for HLA-A, -B, -C, and -D antigens. The Phillip Levine Award Lecture.Am J Clin Pathol. 1978 Feb;69(2):103-20 PMID: 75690
-
Strong association between the HLA-Dw3-related B cell alloantigen -DRw3 and coeliac disease.Scand J Gastroenterol. 1978;13(2):229-33 PMID: 76332
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