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PMID: 3878239 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria.

Clinical and experimental immunology ·Vol. 61 ·No. 3 ·1985-09-00 ·Pages 503-8

Kono DH, Ogasawara M, Effros RB, Park MS, Waldord RL, Yu DT

Abstract

A monoclonal antibody, Ye-1, was generated by immunizing BALB/c mice with Yersinia enterocolitica. This antibody also reacted with all of 12 B27 positive lymphoblastoid cell lines, but only four of 31 B27 negative ones. Three of the four reactive B27 negative cell lines were B7 positive. A B27 positive cell line which has lost the B27 expression because of experimentally-induced mutation became unreactive with the Ye-1. These findings support the possibility that there is cross-reactivity between HLA-B27 antigens and Y. enterocolitica.

MeSH Terms
Animals Antibodies, Monoclonal/immunology Antigens, Bacterial/immunology Arthritis, Infectious/immunology Arthritis, Reactive/immunology Cell Line Cross Reactions Enzyme-Linked Immunosorbent Assay HLA Antigens/analysis,immunology HLA-B27 Antigen Humans Leukemia, Experimental/immunology Mice Mice, Inbred BALB C Yersinia enterocolitica/immunology
Chemicals
Antibodies, Monoclonal Antigens, Bacterial HLA Antigens HLA-B27 Antigen
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Kono D H
Ogasawara M
Effros R B
Park M S
Waldord R L
Yu D T
References (10)
10 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1985-09-00
Pages
503-8
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1577260
Subset
IM
Grants
NIAID NIH HHS · AI07126 · United States
NIAID NIH HHS · AI10088 · United States
NIADDK NIH HHS · AM28536 · United States
External Links
PubMed source PMC Full Text View journal details
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