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PMID: 3881408 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Separate resistances to arsenate and arsenite (antimonate) encoded by the arsenical resistance operon of R factor R773.

Journal of bacteriology ·Vol. 161 ·No. 2 ·1985-02-00 ·Pages 758-63

Chen CM, Mobley HL, Rosen BP

Abstract

The arsenical resistance operon of R factor R773 was analyzed by subcloning and insertional inactivation. The operon was found to have two functional regions, the promoter-proximal region encoding resistance to arsenite and antimonate and the promoter-distal region encoding arsenate resistance. A unique 1.6-kilobase fragment was shown to be sufficient to encode arsenate resistance and produce arsenate extrusion from intact cells.

MeSH Terms
Arsenates/metabolism,pharmacology Arsenic/metabolism,pharmacology Arsenites Cloning, Molecular Escherichia coli/drug effects,genetics Mutation Operon Peptide Biosynthesis R Factors
Chemicals
Arsenates Arsenites arsenite Arsenic arsenic acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Chen C M
Mobley H L
Rosen B P
References (19)
19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.161.2.758-763.1985
Published
1985-02-00
Pages
758-63
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC214947
Subset
IM
Grants
NIAID NIH HHS · AI19793 · United States
External Links
PubMed source DOI: 10.1128/jb.161.2.758-763.1985 PMC Full Text View journal details
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