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PMID: 3889906 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

High-frequency meiotic gene conversion between repeated genes on nonhomologous chromosomes in yeast.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 82 ·No. 10 ·1985-05-00 ·Pages 3350-4

Jinks-Robertson S, Petes TD

Abstract

We have used a genetic system that allows detection of meiotic recombination events between repeated sequences on nonhomologous chromosomes in the yeast Saccharomyces cerevisiae. We have found that recombination between these sequences occurs at a frequency of about 0.5%, and the events observed were nonreciprocal (gene conversions). Surprisingly, the frequency of conversion between the repeated genes on nonhomologous chromosomes observed in this study is similar to that observed between allelic genes. This result is discussed in connection with the role of the synaptonemal complex in meiotic recombination and with the relationship between reciprocal and nonreciprocal recombination.

MeSH Terms
Chromosome Mapping Gene Conversion Histidine/genetics Meiosis Mitosis Recombination, Genetic Repetitive Sequences, Nucleic Acid Saccharomyces cerevisiae/genetics
Chemicals
Histidine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Jinks-Robertson S
Petes T D
References (37)
37 references, click to expand
  1. Synaptic structures in the nuclei of sporulating yeast, Saccharomyces cerevisiae (Hansen).
    J Cell Sci. 1971 Nov;9(3):665-77 PMID: 4112475
  2. Meiotic roles of crossing-over and of gene conversion.
    Cold Spring Harb Symp Quant Biol. 1984;49:23-9 PMID: 6597757
  3. Detection of specific sequences among DNA fragments separated by gel electrophoresis.
    J Mol Biol. 1975 Nov 5;98(3):503-17 PMID: 1195397
  4. Electron microscopic observations on the meiotic karyotype of diploid and tetraploid Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 1975 Dec;72(12):5056-60 PMID: 1108011
  5. Synaptonemal complex and chromosome structure.
    Annu Rev Genet. 1975;9:91-109 PMID: 1108770
  6. Meiotic recombination and synaptonemal complexes in Saccharomyces cerevisiae.
    Mol Gen Genet. 1978 Oct 30;166(2):151-9 PMID: 370542
  7. Replacement of chromosome segments with altered DNA sequences constructed in vitro.
    Proc Natl Acad Sci U S A. 1979 Oct;76(10):4951-5 PMID: 388424
  8. Genetic mapping of arg1 and arg8 in Saccharomyces cerevisiae by trisomic analysis combined with interallelic complementation.
    J Bacteriol. 1980 Jan;141(1):270-4 PMID: 6986360
  9. Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments.
    Gene. 1979 Dec;8(1):17-24 PMID: 395030
  10. Unequal crossing over in the ribosomal DNA of Saccharomyces cerevisiae.
    Nature. 1980 Apr 3;284(5755):426-30 PMID: 6987539
  11. Unequal meiotic recombination within tandem arrays of yeast ribosomal DNA genes.
    Cell. 1980 Mar;19(3):765-74 PMID: 6988084
  12. A physical, genetic and transcriptional map of the cloned his3 gene region of Saccharomyces cerevisiae.
    J Mol Biol. 1980 Jan 25;136(3):309-32 PMID: 6246242
  13. Recombination of dispersed repeated DNA sequences in yeast.
    Science. 1980 Sep 19;209(4463):1380-4 PMID: 6251545
  14. Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.
    Cell. 1980 Oct;21(3):627-38 PMID: 7438203
  15. Intrachromosomal gene conversion in yeast.
    Nature. 1981 Jan 15;289(5794):144-8 PMID: 7005693
  16. Gene conversion: some implications for immunoglobulin genes.
    Cell. 1981 Jun;24(3):592-4 PMID: 7018693
  17. Gene conversion between duplicated genetic elements in yeast.
    Nature. 1981 Jul 23;292(5821):306-11 PMID: 6265790
  18. The cyc1-11 mutation in yeast reverts by recombination with a nonallelic gene: composite genes determining the iso-cytochromes c.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6334-8 PMID: 6273865
  19. Yeast transformation: a model system for the study of recombination.
    Proc Natl Acad Sci U S A. 1981 Oct;78(10):6354-8 PMID: 6273866
  20. Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase.
    Cell. 1982 Jan;28(1):145-54 PMID: 7039847
  21. Movement of yeast transposable elements by gene conversion.
    Proc Natl Acad Sci U S A. 1982 Sep;79(18):5621-5 PMID: 6291054
  22. Recombination between dispersed serine tRNA genes in Schizosaccharomyces pombe.
    Nature. 1982 Nov 18;300(5889):225-31 PMID: 6924071
  23. Recombination between genes located on nonhomologous chromosomes in Saccharomyces cerevisiae.
    Genetics. 1982 Jul-Aug;101(3-4):369-404 PMID: 6757052
  24. Genetic selection for reciprocal translocation at chosen chromosomal sites in Saccharomyces cerevisiae.
    Mol Cell Biol. 1982 Sep;2(9):1025-32 PMID: 6294503
  25. The structure of a mutant H-2 gene suggests that the generation of polymorphism in H-2 genes may occur by gene conversion-like events.
    Nature. 1983 Feb 24;301(5902):671-4 PMID: 6828150
  26. One-step gene disruption in yeast.
    Methods Enzymol. 1983;101:202-11 PMID: 6310324
  27. Recombination between sequences in nonhomologous positions.
    Proc Natl Acad Sci U S A. 1983 Sep;80(18):5675-9 PMID: 6351064
  28. Evidence for intrachromosomal gene conversion in cultured mouse cells.
    Cell. 1983 Nov;35(1):157-65 PMID: 6578876
  29. Gene conversion and associated reciprocal recombination are separable events in vegetative cells of Saccharomyces cerevisiae.
    Proc Natl Acad Sci U S A. 1983 Nov;80(22):6912-6 PMID: 6359159
  30. Identification of a Ty insertion within the coding sequence of the S. cerevisiae URA3 gene.
    Mol Gen Genet. 1984;193(3):557-60 PMID: 6323928
  31. Intrachromosomal movement of genetically marked Saccharomyces cerevisiae transposons by gene conversion.
    Mol Cell Biol. 1984 Apr;4(4):703-11 PMID: 6325891
  32. Sexual preference of apparent gene conversion events in MHC genes of mice.
    Nature. 1984 Jun 14-20;309(5969):639-40 PMID: 6728023
  33. The double-strand-break repair model for recombination.
    Cell. 1983 May;33(1):25-35 PMID: 6380756
  34. Gene conversion in the absence of reciprocal recombination.
    Nature. 1984 Aug 30-Sep 5;310(5980):728-9 PMID: 6472456
  35. Resolution of recombination intermediates generated during yeast mating type switching.
    Nature. 1984 Aug 30-Sep 5;310(5980):744-8 PMID: 6382020
  36. Lack of association between intrachromosomal gene conversion and reciprocal exchange.
    Nature. 1984 Aug 30-Sep 5;310(5980):748-53 PMID: 6088989
  37. A general model for genetic recombination.
    Proc Natl Acad Sci U S A. 1975 Jan;72(1):358-61 PMID: 1054510
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.82.10.3350
Published
1985-05-00
Pages
3350-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC397773
Subset
IM
Grants
NCI NIH HHS · CA 19265 · United States
NIGMS NIH HHS · GM 24110 · United States
NIA NIH HHS · K 04 AG 00077 · United States
External Links
PubMed source DOI: 10.1073/pnas.82.10.3350 PMC Full Text View journal details
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