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PMID: 3903613 Published · ppublish English Journal Article Review

Pain relief by antidepressants: possible modes of action.

Pain ·Vol. 23 ·No. 1 ·1985-09-00 ·Pages 1-8

Feinmann C

Abstract

There is evidence that both tricyclic antidepressants and monoamine oxidase inhibitors can relieve chronic pain. There are a number of possible mechanisms for this phenomenon, recent studies suggest that this may be due to an analgesic rather than antidepressant effect.

MeSH Terms
Animals Antidepressive Agents/therapeutic use Antidepressive Agents, Tricyclic/therapeutic use Brain/metabolism Depression/drug therapy,metabolism Humans Monoamine Oxidase Inhibitors/therapeutic use Pain/drug therapy,metabolism Serotonin/metabolism
Chemicals
Antidepressive Agents Antidepressive Agents, Tricyclic Monoamine Oxidase Inhibitors Serotonin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Feinmann Charlotte
Consultant Psychological Medicine, Eastman Dental Hospital, London WC1 U.K.
Article Info
Journal
Pain
Abbr.
Pain
ISSN
0304-3959
DOI
10.1016/0304-3959(85)90223-4
Published
1985-09-00
Pages
1-8
Language
English
Region
United States
NLM ID
7508686
Subset
IM
External Links
PubMed source DOI: 10.1016/0304-3959(85)90223-4 View journal details
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