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PMID: 3905607 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Unimpaired function of human phagocytes in the presence of phagocytosis-resistant group A streptococci.

Infection and immunity ·Vol. 50 ·No. 3 ·1985-12-00 ·Pages 610-3

Manjula BN, Schmidt ML, Fischetti VA

Abstract

The resistance to phagocytosis of the group A streptococci has been attributed mainly to the presence of the surface antigen, M protein. In the present study, we addressed the question of whether the phagocytosis resistance of the group A streptococci is due to their ability to impair the function of the phagocytic cells. The results of these studies demonstrate that the presence of a large excess of a phagocytosis-resistant strain of streptococci does not significantly interfere with either the antibody-independent or the antibody-dependent phagocytosis of streptococci. Apparently, a phagocytosis-resistant strain of streptococci does not bring about a generalized deactivation of the phagocytic plasma membrane. This suggests that if the resistance of the group A streptococci is due to any deactivating influence at all on the phagocytic plasma membrane, it is likely to be confined to the contact area of the cocci with the phagocyte.

MeSH Terms
Antibodies/immunology Humans Phagocytes/immunology Phagocytosis Streptococcus pyogenes/immunology
Chemicals
Antibodies
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Manjula B N
Schmidt M L
Fischetti V A
References (17)
17 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.50.3.610-613.1985
Published
1985-12-00
Pages
610-3
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC261121
Subset
IM
Grants
NIAID NIH HHS · AI11822 · United States
NHLBI NIH HHS · HL36025 · United States
External Links
PubMed source DOI: 10.1128/iai.50.3.610-613.1985 PMC Full Text View journal details
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