recA-independent mutagenicity induced by chloroethylene oxide in E. coli.

Mutation research ·Vol. 152 ·No. 2-3 ·1985-00-00 ·Pages 157-9

Barbin A, Tenenbaum L, Toman Z, Radman M, Bartsch H

Abstract

The mechanism of mutagenicity of chloroethylene oxide (CEO), an ultimate carcinogenic metabolite of vinyl chloride, was investigated in 3 Escherichia coli strains (E. coli "multitest"). In this system, the mutagenicity of CEO was found to be mainly SOS-independent. CEO did not induce recombinational events at a detection level of about 10(-2) recombinants/survivor. Our results indicate that CEO- (or vinyl chloride-) induced bacterial mutagenesis arises mainly from miscoding DNA adducts.

MeSH Terms

Escherichia coli/drug effects,genetics Ethylene Oxide/analogs & derivatives,pharmacology Kinetics Mutagenicity Tests Mutagens Mutation Rec A Recombinases/genetics Species Specificity

Chemicals

Mutagens chloroethylene oxide Rec A Recombinases Ethylene Oxide

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Barbin A

Tenenbaum L

Toman Z

Radman M

Bartsch H

Article Info

Journal

Mutation research

Abbr.

Mutat Res

ISSN

0027-5107

DOI

10.1016/0027-5107(85)90057-0

Published

1985-00-00

Pages

157-9

Language

English

Region

Netherlands

NLM ID

0400763

Subset

External Links

PubMed source DOI: 10.1016/0027-5107(85)90057-0 View journal details

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recA-independent mutagenicity induced by chloroethylene oxide in E. coli.

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