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PMID: 3917973 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Mutation at I-A beta chain prevents experimental autoimmune myasthenia gravis.

Immunogenetics ·Vol. 21 ·No. 1 ·1985-00-00 ·Pages 33-8

Christadoss P, Lindstrom JM, Melvold RW, Talal N

Abstract

Immune response (Ir) gene(s) at the I-A subregion of the mouse H-2 complex influence susceptibility to experimental autoimmune myasthenia gravis (EAMG). To determine the importance of the Ir gene product, the Ia antigens, in EAMG pathogenesis, we studied the degree of EAMG susceptibility of an I-A mutant strain, the B6.C-H-2bm12 (bm12), and its parent B6/Kh. According to the cellular, humoral, biochemical, and clinical manifestations of EAMG, the I-A mutation converted an EAMG susceptible strain (B6/Kh) into a relatively resistant strain (bm12). The relative resistance to EAMG induction in bm12 may be due to the lack of Ia.8 and/or Ia.39 determinants and/or quantitative expression of Ia antigens.

MeSH Terms
Animals Antibody Formation Autoimmune Diseases/genetics,immunology Genes, MHC Class II H-2 Antigens/genetics Histocompatibility Antigens Class II/genetics Immunity, Cellular Mice Mice, Mutant Strains/immunology Myasthenia Gravis/genetics,immunology Receptors, Cholinergic/immunology
Chemicals
H-2 Antigens Histocompatibility Antigens Class II Receptors, Cholinergic
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Christadoss P
Lindstrom J M
Melvold R W
Talal N
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24 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00372239
Published
1985-00-00
Pages
33-8
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00372239 View journal details
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