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PMID: 3918176 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Scrapie PrP 27-30 is a sialoglycoprotein.

Journal of virology ·Vol. 53 ·No. 2 ·1985-02-00 ·Pages 596-606

Bolton DC, Meyer RK, Prusiner SB

Abstract

The major scrapie prion protein, designated PrP 27-30, exhibited both charge and size heterogeneity after purification from infected hamster brains. Eight or more discrete charge isomers of PrP 27-30 with isoelectric points ranging from approximately pH 4.6 to 7.9 were found by using non-equilibrium pH gradient electrophoresis in the first dimension followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the second dimension. The charge isomers were detected by silver staining as well as by radioiodination. The procedures used to disaggregate PrP 27-30 before electrophoresis in the first dimension do not appear to be responsible for the charge heterogeneity. However, heating PrP 27-30 to 100 degrees C for 15 min in 0.1 N NaOH or 0.1 N HCl resulted in modification of the protein and alteration of its electrophoretic pattern. A PrP 27-30 fragment (molecular weight, 17,100 to 21,900) obtained by cyanogen bromide cleavage also exhibited charge and size heterogeneity. Periodic acid-Schiff staining of PrP 27-30 electrophoresed into sodium dodecyl sulfate-polyacrylamide gels demonstrated that carbohydrate residues are attached to the protein. Digestion of PrP 27-30 with neuraminidase and endo-beta-N-acetylglucosaminidase H resulted in significant changes in the isoelectric pH of PrP 27-30 isomers, whereas digestion with alkaline phosphatase had no effect. Our results demonstrate that PrP 27-30 is a sialoglycoprotein; this is consistent with several properties of this protein and of the scrapie prion.

MeSH Terms
Alkaline Phosphatase Centrifugation, Density Gradient Chemical Phenomena Chemistry Cyanogen Bromide Electrophoresis, Polyacrylamide Gel Glycoside Hydrolases Hydrogen-Ion Concentration Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Molecular Weight Neuraminidase Periodic Acid-Schiff Reaction Prions/analysis Sialoglycoproteins/analysis,isolation & purification Viral Proteins/analysis,isolation & purification
Chemicals
Prions Sialoglycoproteins Viral Proteins Alkaline Phosphatase Glycoside Hydrolases Neuraminidase Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase Cyanogen Bromide
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bolton D C
Meyer R K
Prusiner S B
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42 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
Published
1985-02-00
Pages
596-606
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254675
Subset
IM
Grants
NIA NIH HHS · AG02132 · United States
NINDS NIH HHS · NS06849 · United States
NINDS NIH HHS · NS14069 · United States
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