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PMID: 3930444 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.

Japanese journal of cancer research : Gann ·Vol. 76 ·No. 8 ·1985-08-00 ·Pages 672-5

Uehara Y, Hori M, Takeuchi T, Umezawa H

Abstract

During the course of screening of agents active in converting the transformed morphology of Rous sarcoma virus-infected rat kidney cells to the normal morphology, we identified an active substance produced by Streptomyces sp. MH237-CF8 as herbimycin. Herbimycin converted almost all cells into the normal morphology. The antibiotic was found to be an inhibitor of p60src-associated protein kinase in the cells.

MeSH Terms

Animals Benzoquinones Cell Transformation, Viral/drug effects Cells, Cultured Kidney Lactams, Macrocyclic Oncogene Protein pp60(v-src) Oncogene Proteins, Viral/antagonists & inhibitors Phenylglyoxal/analogs & derivatives Protein-Tyrosine Kinases/antagonists & inhibitors,biosynthesis Quinones/pharmacology Rats Retroviridae Proteins/antagonists & inhibitors,biosynthesis Rifabutin/analogs & derivatives

Chemicals

Benzoquinones Lactams, Macrocyclic Oncogene Proteins, Viral Quinones Retroviridae Proteins Rifabutin herbimycin Protein-Tyrosine Kinases Oncogene Protein pp60(v-src) Phenylglyoxal benzil

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Uehara Y

Hori M

Takeuchi T

Umezawa H

Article Info

Journal

Japanese journal of cancer research : Gann

Abbr.

Jpn J Cancer Res

ISSN

0910-5050

Published

1985-08-00

Pages

672-5

Language

English

Region

Japan

NLM ID

8509412

Subset

Grants

NCI NIH HHS · N01-CM-47593 · United States

External Links

PubMed source

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Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.

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