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PMID: 3933816 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Anti-tumour activity of Lactobacillus casei on Lewis lung carcinoma and line-10 hepatoma in syngeneic mice and guinea pigs.

Cancer immunology, immunotherapy : CII ·Vol. 20 ·No. 1 ·1985-00-00 ·Pages 18-22

Matsuzaki T, Yokokura T, Azuma I

Abstract

The anti-tumour activity of Lactobacillus casei YIT 9018 (LC 9018) on Lewis lung carcinoma (3LL) in C57BL/6 mice and line-10 hepatoma in strain-2 guinea pigs was examined. Intravenous injection of LC 9018 was effective for inhibition of pulmonary metastases in C57BL/6 mice after s.c. inoculation with 3LL tumours. Intralesional (i.l.) injection of LC 9018 was also effective for both prolongation of the survival period and inhibition of pulmonary metastases in 3LL tumour-bearing mice. The combination treatment of i.l. and i.v. injections of LC 9018 before or after surgical excision of the primary tumour remarkably inhibited the pulmonary metastases after inoculation with 3LL tumour. Intralesional injection of LC 9018 was effective for regression of the established tumours of line-10 hepatoma inoculated i.d. and for induction of systemic tumour immunity in strain-2 guinea pigs.

MeSH Terms
Animals Carcinoma/therapy Guinea Pigs Immunotherapy Lactobacillus casei/immunology Liver Neoplasms, Experimental/therapy Mice Neoplasm Metastasis Neoplasms, Experimental/therapy
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Matsuzaki T
Yokokura T
Azuma I
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30 references, click to expand
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Article Info
Journal
Cancer immunology, immunotherapy : CII
Abbr.
Cancer Immunol Immunother
ISSN
0340-7004
DOI
10.1007/BF00199768
Published
1985-00-00
Pages
18-22
Language
English
Region
Germany
NLM ID
8605732
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00199768 View journal details
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