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PMID: 3935045 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

In vitro activity of Ro 15-8074, a new oral cephalosporin, against Neisseria gonorrhoeae.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 3 ·1985-09-00 ·Pages 461-3

Ng WS, Chau PY, Leung YK, Wong PC

Abstract

Ro 15-8074, a new cephalosporin the pivaloyloxymethylester of which (Ro 15-8075) is orally absorbable, showed greater in vitro activity than cefaclor against 48 Neisseria gonorrhoeae strains, including 25 penicillinase-producing strains. Unlike cefaclor, Ro 15-8074 was unaffected by increase in inoculum size, and it exhibited a remarkable stability against gonococcal beta-lactamase hydrolysis.

MeSH Terms
Amoxicillin/metabolism,pharmacology Amoxicillin-Potassium Clavulanate Combination Cefaclor/metabolism,pharmacology Ceftizoxime/analogs & derivatives Cephalosporins/metabolism,pharmacology Clavulanic Acids/pharmacology In Vitro Techniques Microbial Sensitivity Tests Neisseria gonorrhoeae/drug effects beta-Lactamases/metabolism
Chemicals
Cephalosporins Clavulanic Acids cefetamet Cefaclor Amoxicillin-Potassium Clavulanate Combination Amoxicillin Ceftizoxime beta-Lactamases cefetamet pivoxyl
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Ng W S
Chau P Y
Leung Y K
Wong P C
References (9)
9 references, click to expand
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  5. In vitro antimicrobial susceptibilities of penicillinase-producing and non-penicillinase-producing strains of Neisseria gonorrhoeae isolated in Durban, South Africa.
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  6. Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.
    Br J Vener Dis. 1982 Jun;58(3):176-9 PMID: 6805850
  7. Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.
    Antimicrob Agents Chemother. 1982 Nov;22(5):923-5 PMID: 6983863
  8. In vitro antimicrobial activity of eight new beta-lactam antibiotics against penicillin-resistant Neisseria gonorrhoeae.
    Antimicrob Agents Chemother. 1983 Apr;23(4):541-4 PMID: 6407392
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.28.3.461
Published
1985-09-00
Pages
461-3
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC180277
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.28.3.461 PMC Full Text View journal details
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