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PMID: 3936092 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Apomorphine anorexia: a behavioural and neuropharmacological analysis.

Psychopharmacology ·Vol. 87 ·No. 3 ·1985-00-00 ·Pages 351-6

Willner P, Towell A, Muscat R

Abstract

Anorectic effects of apomorphine were studied in a microstructural analysis paradigm. Low doses of apomorphine (less than 0.1 mg/kg SC) reduced food intake, by reducing both the rate of eating and eating time. The neuroleptics haloperidol and thioridazine blocked the effect of apomorphine on eating time, but not on eating rate. Anorectic effects elicited by apomorphine administration to the ventral tegmental area and, to a lesser extent, the substantia nigra were mediated by a selective reduction of eating time. Effects of apomorphine on eating time appear to result from an action at presynaptic dopamine receptors; the mechanism of the effect of apomorphine on eating rate is unclear.

MeSH Terms
Animals Anorexia/chemically induced Apomorphine/antagonists & inhibitors,pharmacology Brain Mapping Feeding Behavior/drug effects Feeding and Eating Disorders/chemically induced Haloperidol/pharmacology Male Rats Receptors, Dopamine/drug effects Substantia Nigra/drug effects Tegmentum Mesencephali/drug effects Thioridazine/pharmacology
Chemicals
Receptors, Dopamine Haloperidol Apomorphine Thioridazine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Willner P
Towell A
Muscat R
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19 references, click to expand
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Article Info
Journal
Psychopharmacology
Abbr.
Psychopharmacology (Berl)
ISSN
0033-3158
DOI
10.1007/BF00432720
Published
1985-00-00
Pages
351-6
Language
English
Region
Germany
NLM ID
7608025
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00432720 View journal details
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