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PMID: 3937549 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Terfenadine and placebo compared in the treatment of chronic idiopathic urticaria: a randomised double-blind study.

British journal of clinical pharmacology ·Vol. 20 ·No. 6 ·1985-12-00 ·Pages 639-41

Ferguson J, MacDonald KJ, Kenicer KJ

Abstract

Terfenadine, a potent and non-sedative antihistamine, was shown to be effective in chronic idiopathic urticaria in a double-blind crossover placebo controlled trial. An oral twice daily 60 mg dose of terfenadine was given and itch and wheal parameters were assessed daily. Despite the overall effectiveness of terfenadine, a variable response was noted which was similar to that shown in previous studies with other antihistamines.

MeSH Terms
Adult Aged Benzhydryl Compounds/adverse effects,therapeutic use Chronic Disease Clinical Trials as Topic Double-Blind Method Female Humans Male Middle Aged Random Allocation Terfenadine Urticaria/drug therapy
Chemicals
Benzhydryl Compounds Terfenadine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ferguson J
MacDonald K J
Kenicer K J
References (10)
10 references, click to expand
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    Clin Allergy. 1984 Mar;14(2):139-41 PMID: 6423314
  6. Combined H1 and H2 antihistamine therapy in chronic urticaria.
    Arch Dermatol. 1981 Jul;117(7):404-7 PMID: 6114712
  7. Performance studies with the H1-histamine receptor antagonists, astemizole and terfenadine.
    Br J Clin Pharmacol. 1982 Feb;13(2):199-202 PMID: 6120713
  8. Terfenadine, the first non-sedating antihistamine.
    Arzneimittelforschung. 1982;32(9a):1154-6 PMID: 6129860
  9. Sedation and antihistaminics.
    Arzneimittelforschung. 1982;32(9a):1193-5 PMID: 6129866
  10. The pathogenic basis of urticaria and angioedema: recent advances.
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Article Info
Journal
British journal of clinical pharmacology
Abbr.
Br J Clin Pharmacol
ISSN
0306-5251
DOI
10.1111/j.1365-2125.1985.tb05122.x
Published
1985-12-00
Pages
639-41
Language
English
Region
England
NLM ID
7503323
PMCID
PMC1400841
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2125.1985.tb05122.x PMC Full Text View journal details
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