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PMID: 3937845 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The thin filaments of smooth muscles.

Journal of muscle research and cell motility ·Vol. 6 ·No. 6 ·1985-12-00 ·Pages 669-708

Marston SB, Smith CW

Abstract

Contraction in vertebrate smooth and striated muscles results from the interaction of the actin filaments with crossbridges arising from the myosin filaments. The functions of the actin based thin filaments are (1) interaction with myosin to produce force; (2) regulation of force generation in response to Ca2+ concentration; and (3) transmission of the force to the ends of the cell. The major protein components of smooth muscle thin filaments are actin, tropomyosin and caldesmon, present in molar ratios of 28:4:1 respectively. Other smooth muscle proteins which may be associated with the thin filaments in the cell are filamin, vinculin, alpha-actinin, myosin light chain kinase and calmodulin. We have reviewed the structural and functional properties of these proteins and where possible we have suggested what their function and mechanism of action may be. We propose that actin and tropomyosin are involved in the force producing interaction with myosin, and that this interaction is controlled by a Ca2+-dependent mechanism involving caldesmon, tropomyosin and calmodulin. Vinculin, alpha-actinin and filamin appear to be involved in the attachment of the thin filaments to the cell membrane and their spatial organization within the cell. We conclude that the filaments of smooth muscles share many common properties with those from skeletal muscle, but that they are also quite distinct in terms of both their caldesmon based regulatory mechanism and their mode of organization into a contractile apparatus.

MeSH Terms
Actinin/analysis Actins/analysis Animals Calcium/physiology Calmodulin/physiology Calmodulin-Binding Proteins/analysis Contractile Proteins/analysis Filamins Humans Microfilament Proteins/analysis Molecular Weight Muscle Proteins/analysis,isolation & purification Muscle, Smooth/analysis,ultrastructure Myosin-Light-Chain Kinase Myosins/analysis Phosphorylation Protein Kinases/analysis Tropomyosin/analysis Vinculin
Chemicals
Actins Calmodulin Calmodulin-Binding Proteins Contractile Proteins Filamins Microfilament Proteins Muscle Proteins Tropomyosin Actinin Vinculin Protein Kinases Myosin-Light-Chain Kinase Myosins Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Marston S B
Smith C W
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Article Info
Journal
Journal of muscle research and cell motility
Abbr.
J Muscle Res Cell Motil
ISSN
0142-4319
DOI
10.1007/BF00712237
Published
1985-12-00
Pages
669-708
Language
English
Region
Netherlands
NLM ID
8006298
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00712237 View journal details
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