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PMID: 3955883 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Humoral immune response in patients with IgA and IgM glomerulonephritis.

Clinical and experimental immunology ·Vol. 63 ·No. 1 ·1986-01-00 ·Pages 228-33

Pasternack A, Mustonen J, Leinikki P

Abstract

A single dose of inactivated mumps virus vaccine was administered to male patients with IgA glomerulonephritis (IgA-GN), IgM glomerulonephritis (IgM-GN) and to healthy males. Antibodies to mumps virus were determined using an enzyme-linked immunosorbent assay. Patients with IgA-GN showed a higher and more sustained IgG and IgA antibody response compared to patients with IgM-GN or healthy controls. Before vaccination, patients with IgM-GN had higher levels of IgG antibodies than the controls or those with IgA-GN. However, the IgA antibody and IgG responses after vaccination were low. IgM antibody responses did not vary among the groups studied. It is concluded that patients with IgA-GN are high responders for IgA and IgG antibody production. Patients with IgM-GN are low responders, especially for IgA antibody.

MeSH Terms
Adolescent Adult Antibodies, Viral/biosynthesis Complement C3/analysis Complement C4/analysis Glomerulonephritis/immunology Glomerulonephritis, IGA/immunology Humans Immunoglobulin A/biosynthesis Immunoglobulin G/biosynthesis Immunoglobulin M/biosynthesis Male Middle Aged Mumps Vaccine/immunology
Chemicals
Antibodies, Viral Complement C3 Complement C4 Immunoglobulin A Immunoglobulin G Immunoglobulin M Mumps Vaccine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Pasternack A
Mustonen J
Leinikki P
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24 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1986-01-00
Pages
228-33
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1577335
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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