Home LiteratureArticle Details

PMID: 3957003 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Construction of human linkage maps: likelihood calculations for multilocus linkage analysis.

Genetic epidemiology ·Vol. 3 ·No. 1 ·1986-00-00 ·Pages 39-52

Lathrop GM, Lalouel JM, White RL

Abstract

Methods are given for efficient calculation of the likelihood for multilocus linkage in families comprised of grandparents, parents, and children. Such families are being used in large-scale cooperative efforts to build a detailed linkage map of the human genome. The methods are illustrated by an application to loci on chromosome 13.

MeSH Terms

Chromosome Mapping Chromosomes, Human, 13-15 Crosses, Genetic Factor Analysis, Statistical Female Genetic Linkage Genetics, Medical Genotype Humans Male Mathematics Models, Genetic Pedigree Probability Recombination, Genetic

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Lathrop G M

Lalouel J M

White R L

Article Info

Journal

Genetic epidemiology

Abbr.

Genet Epidemiol

ISSN

0741-0395

DOI

10.1002/gepi.1370030105

Published

1986-00-00

Pages

39-52

Language

English

Region

United States

NLM ID

8411723

Subset

External Links

PubMed source DOI: 10.1002/gepi.1370030105 View journal details

Analysis Services

Construction of human linkage maps: likelihood calculations for multilocus linkage analysis.

Contact

WeChat Official Account