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PMID: 3960133 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

DNA bending at adenine . thymine tracts.

Nature ·Vol. 320 ·No. 6062 ·1986-00-00 ·Pages 501-6

Koo HS, Wu HM, Crothers DM

Abstract

Intrinsic bending of DNA molecules results from local structural polymorphism in regions of homopolymeric dA . dT which are at least 4 base pairs long; the A . T tracts must be repeated in phase with the helix screw. Bending, in the direction of base-pair tilt rather than roll, occurs at the junctions between the A . T tract and adjacent B-DNA, with a larger angle at the 3' than at the 5' end of the A tract.

MeSH Terms
Adenine Base Sequence DNA/analysis Electrophoresis, Polyacrylamide Gel Nucleic Acid Conformation Poly dA-dT Polymorphism, Genetic Repetitive Sequences, Nucleic Acid Temperature Thymine
Chemicals
Poly dA-dT DNA Adenine Thymine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Koo H S
Wu H M
Crothers D M
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1986-00-00
Pages
501-6
Language
English
Region
England
NLM ID
0410462
Subset
IM
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