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PMID: 3967923 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Murine malaria: resistance of AXB/BXA recombinant inbred mice to Plasmodium chabaudi.

Infection and immunity ·Vol. 47 ·No. 2 ·1985-02-00 ·Pages 452-6

Stevenson MM, Skamene E

Abstract

The level of resistance to infection with Plasmodium chabaudi is genetically controlled. We have previously reported that a single dominant gene is responsible for the variation in host resistance to malaria between susceptible A/J- and resistant C57BL-derived mice. In the present study, recombinant inbred strain analysis was performed with AXB/BXA recombinant inbred strains derived from A/J and C57BL/6 progenitors. Typing of 17 AXB/BXA recombinant inbred strains confirmed the unigenic control of inheritance in this particular strain combination and allowed us to demonstrate genetic linkage between the traits of resistance (defined as a prolonged survival and a low peak parasitemia) and the magnitude of splenomegaly. The influence of sex on the course of infection, which we previously reported in the examination of segregating populations (Stevenson et al., Infect. Immun. 38:80-88, 1982), was again demonstrated in the survey of RI strains.

MeSH Terms
Animals Crosses, Genetic Female Immunity, Innate Malaria/genetics,immunology,veterinary Male Mice Mice, Inbred Strains/genetics,immunology Rodent Diseases/genetics,immunology Sex Factors Spleen/immunology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Stevenson M M
Skamene E
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25 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.47.2.452-456.1985
Published
1985-02-00
Pages
452-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC263191
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.47.2.452-456.1985 PMC Full Text View journal details
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