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PMID: 3968171 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Reversal of the posttranslational modification on Chlamydomonas flagellar alpha-tubulin occurs during flagellar resorption.

The Journal of cell biology ·Vol. 100 ·No. 2 ·1985-02-00 ·Pages 457-62

L'Hernault SW, Rosenbaum JL

Abstract

We previously have shown that a posttranslational modification of alpha-tubulin takes place in the flagellum during Chlamydomonas flagellar assembly (L'Hernault, S. W., and J. L. Rosenbaum, 1983, J. Cell Biol., 97:258-263). In this report, we show that the posttranslationally modified alpha-3 tubulin is changed back to its unmodified alpha-1 precursor form during the microtubular disassembly that takes place during flagellar resorption. These data indicate that the addition and removal of a posttranslational modification on alpha-tubulin might be a control step in the assembly and disassembly of flagella.

MeSH Terms
Chlamydomonas/metabolism,ultrastructure Flagella/metabolism,ultrastructure Kinetics Microtubules/metabolism Protein Processing, Post-Translational Tubulin/metabolism
Chemicals
Tubulin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
L'Hernault S W
Rosenbaum J L
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37 references, click to expand
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.100.2.457
Published
1985-02-00
Pages
457-62
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2113451
Subset
IM
Grants
NIGMS NIH HHS · GM 07223 · United States
NIGMS NIH HHS · GM 14642 · United States
External Links
PubMed source DOI: 10.1083/jcb.100.2.457 PMC Full Text View journal details
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