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PMID: 3973056 Published · ppublish English Case Reports Journal Article

Postsplenectomy sepsis 10 years or more after operation.

Journal of clinical pathology ·Vol. 38 ·No. 3 ·1985-03-00 ·Pages 309-11

Evans DI

Abstract

Three new cases (two fatal) of postsplenectomy sepsis occurring 14, 25, and 26 years after operation for hereditary spherocytosis are described. There are now 25 cases in the published work in which this complication occurred 10 or more years after operation, 14 of which were fatal. The mean age of onset is 37 years. The features of the disease are similar to those seen in other postsplenectomy infections, and pneumococcal infection was responsible in 19 cases (76%). The major predisposing illnesses were trauma, hereditary spherocytosis, and idiopathic thrombocytopenia.

MeSH Terms
Adult Female Humans Male Meningitis, Pneumococcal/etiology Meningococcal Infections/etiology Postoperative Complications Spherocytosis, Hereditary/surgery Splenectomy Time Factors
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Evans D I
References (29)
29 references, click to expand
  1. Splenectomy in childhood and the hazard of overwhelming infection.
    Pediatrics. 1969 May;43(5):886-9 PMID: 4181425
  2. Multiple coagulative defects in a patient with the Waterhouse-Friderichsen syndrome.
    Ann Intern Med. 1962 Apr;56:627-32 PMID: 14490551
  3. The syndrome of asplenia, pneumococcal sepsis, and disseminated intravascular coagulation.
    Ann Intern Med. 1970 Mar;72(3):389-93 PMID: 5415422
  4. Intravascular coagulation associated with pneumococcal bacteremia and symmetrical peripheral gangrene.
    Arch Intern Med. 1970 May;125(5):876-8 PMID: 5424498
  5. Hyposplenism and overwhelming pneumococcal infection: a reappraisal.
    Am J Med Sci. 1971 Aug;262(2):101-7 PMID: 5168937
  6. Splenectomy in childhood: a review of 1413 cases.
    J Pediatr Surg. 1972 Aug-Sep;7(4):382-8 PMID: 5049847
  7. Haemophilus influenzae meningitis in adults.
    Br Med J. 1974 Jun 1;2(5917):463-5 PMID: 4546008
  8. Letter: Infections in asplenic adults.
    Br Med J. 1974 Jul 27;3(5925):254-5 PMID: 4546489
  9. Possible pathogenetic role of capsular antigens in fulminant pneumococcal disease with disseminated intravascular coagulation (DIC).
    Am J Med. 1974 Dec;57(6):889-96 PMID: 4139894
  10. Fatal pneumococcal meningitis in adults following splenectomy: two case reports and a review of the literature.
    J R Nav Med Serv. 1973 Winter;59(3):102-14 PMID: 4804826
  11. Fatal pneumococcal septicemia with disseminated intravascular coagulation following splenectomy.
    J Med Soc N J. 1975 Sep;72(9):730-1 PMID: 1059787
  12. Overwhelming pneumococcal sepsis 25 years after splenectomy.
    Am J Med Sci. 1975 Nov-Dec;270(3):523-4 PMID: 1211412
  13. Splenectomy in childhood: a review in England and Wales, 1960-4.
    Br J Surg. 1976 Jan;63(1):36-43 PMID: 1267873
  14. Immunological impairment and susceptibility to infection after splenectomy.
    JAMA. 1976 Sep 20;236(12):1376-7 PMID: 989094
  15. A.H.A. committee report. Prevention of rheumatic fever.
    Circulation. 1977 Jan;55(1 Suppl):1-4 PMID: 830195
  16. The morbidity and mortality of splenectomy in childhood.
    Ann Surg. 1977 Mar;185(3):307-10 PMID: 557312
  17. Overwhelming postsplenectomy infection.
    Am J Hematol. 1977;2(2):193-201 PMID: 329670
  18. Splenectomy and infection.
    Arch Intern Med. 1977 Nov;137(11):1516-7 PMID: 921436
  19. Fulminant pneumococcal infections in 'normal' asplenic hosts.
    Arch Intern Med. 1977 Nov;137(11):1526-30 PMID: 921438
  20. Death from type 6 pneumococcal septicemia in a vaccinated child with sickle-cell disease.
    N Engl J Med. 1979 Jan 18;300(3):143 PMID: 31564
  21. The syndrome of pneumococcemia, disseminated intravascular coagulation and asplenia.
    Can Med Assoc J. 1979 Jul 7;121(1):57-61 PMID: 38002
  22. Kala-azar of longstanding evolution in an asplenic patient.
    Trans R Soc Trop Med Hyg. 1979;73(3):347-8 PMID: 473333
  23. Human infection from an unidentified erythrocyte-associated bacterium.
    N Engl J Med. 1979 Oct 25;301(17):897-900 PMID: 113680
  24. Postsplenectomy pneumococcemia in adults.
    Arch Pathol Lab Med. 1980 May;104(5):258-60 PMID: 6892758
  25. Post-splenectomy septicemia in Hodgkin's disease and other disorders.
    Acta Chir Scand. 1980;146(8):569-75 PMID: 7223296
  26. Fulminating pneumococcal septicaemia and meningitis in an adult twenty years after splenectomy for a ruptured spleen.
    Neth J Surg. 1982 Dec;34(5):222-4 PMID: 7162682
  27. Splenectomy: indications, hazards and alternatives.
    Br J Surg. 1984 Mar;71(3):173-80 PMID: 6697116
  28. Fatal post-splenectomy sepsis despite prophylaxis with penicillin and pneumococcal vaccine.
    Lancet. 1984 May 19;1(8386):1124 PMID: 6144854
  29. Infection and the spleen: association between hyposplenism, pneumococcal sepsis and disseminated intravascular coagulation.
    Med J Aust. 1969 Jun 14;1(24):1213-9 PMID: 4894854
Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.38.3.309
Published
1985-03-00
Pages
309-11
Language
English
Region
England
NLM ID
0376601
PMCID
PMC499131
Subset
IM
External Links
PubMed source DOI: 10.1136/jcp.38.3.309 PMC Full Text View journal details
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