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PMID: 3973970 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2.

Journal of virology ·Vol. 53 ·No. 3 ·1985-03-00 ·Pages 966-8

Riviere Y, Ahmed R, Southern PJ, Buchmeier MJ, Dutko FJ, Oldstone MB

Abstract

The lymphocytic choriomeningitis virus (LCMV) genome consists of a large RNA segment and a small RNA segment. The three major structural proteins of this virus are an internal nucleoprotein and two surface glycoproteins. Intertypic reassortants between the Armstrong and WE strains of LCMV were made to map proteins encoded by the LCMV genome segments. Using monoclonal antibodies specific for the nucleoprotein and the glycoproteins of WE and Armstrong, we showed that the small RNA segment of LCMV codes for the three major structural polypeptides.

MeSH Terms

Animals Antibodies, Monoclonal/immunology Cricetinae Crosses, Genetic Glycoproteins/genetics Lymphocytic choriomeningitis virus/genetics Nucleoproteins/genetics RNA, Viral/genetics Viral Proteins/genetics Viral Structural Proteins

Chemicals

Antibodies, Monoclonal Glycoproteins Nucleoproteins RNA, Viral Viral Proteins Viral Structural Proteins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Riviere Y

Ahmed R

Southern P J

Buchmeier M J

Dutko F J

Oldstone M B

References (11)

11 references, click to expand

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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.53.3.966-968.1985

Published

1985-03-00

Pages

966-8

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC254733

Subset

Grants

NIA NIH HHS · AG-04342 · United States

NIAID NIH HHS · AI-09484 · United States

NINDS NIH HHS · NS-12428 · United States

External Links

PubMed source DOI: 10.1128/JVI.53.3.966-968.1985 PMC Full Text View journal details

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The S RNA segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoproteins 1 and 2.

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