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PMID: 3973973 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein.

Journal of virology ·Vol. 53 ·No. 3 ·1985-03-00 ·Pages 990-3

Machida CA, Bestwick RK, Kabat D

Abstract

A mutant Rauscher spleen focus-forming virus (mutant 4-3) that causes mild splenic erythroblastosis in mice has a 44-base-pair deletion in the 3' region of its envelope glycoprotein (env) gene. The encoded glycoprotein terminates prematurely, lacks a hydrophobic membrane anchor, and has a shortened intracellular lifespan. An active site for causing erythroblast proliferation may occur in the undamaged amino-terminal domain of the env glycoprotein.

MeSH Terms
Base Sequence Chromosome Deletion Erythroblasts/pathology Glycoproteins/analysis Mutation Rauscher Virus/genetics,pathogenicity Spleen/pathology Viral Envelope Proteins/analysis,genetics
Chemicals
Glycoproteins Viral Envelope Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Machida C A
Bestwick R K
Kabat D
References (27)
27 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.53.3.990-993.1985
Published
1985-03-00
Pages
990-3
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254740
Subset
IM
Grants
NCI NIH HHS · CA 25810 · United States
Databases
GENBANK
M10407
External Links
PubMed source DOI: 10.1128/JVI.53.3.990-993.1985 PMC Full Text View journal details
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