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PMID: 3973979 Published · ppublish English Journal Article

Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes.

Journal of virology ·Vol. 54 ·No. 1 ·1985-04-00 ·Pages 229-32

Perucho M, Esteban M

Abstract

The rodent established cell lines LTk- and NIH 3T3 have been used as recipients in gene transfer experiments to study the effect of interferon treatment on the genetic and oncogenic transformation by several genes of viral and cellular origin. Our results show that interferon severely inhibits, to a similar extent, the stable transformation of Ltk- and NIH 3T3 cells by the chicken thymidine kinase (tk) gene, Ecogpt gene, simian virus 40, v-Ha-ras, and human c-Ha-ras and c-Ki-ras oncogenes. These results are consistent with an inhibition by interferon at the level of stabilization or integration, or both, of exogenous DNA sequences in the recipient cells, with an apparent effect on gene expression.

MeSH Terms
Animals Cell Transformation, Neoplastic/drug effects Cell Transformation, Viral/drug effects Cells, Cultured Cloning, Molecular Genes, Viral Interferon Type I/pharmacology Oncogenes Transfection
Chemicals
Interferon Type I
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Perucho M
Esteban M
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24 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.54.1.229-232.1985
Published
1985-04-00
Pages
229-32
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC254782
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.54.1.229-232.1985 PMC Full Text View journal details
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