Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.

Applied and environmental microbiology ·Vol. 49 ·No. 1 ·1985-01-00 ·Pages 250-2

Corthier G, Dubos F, Raibaud P

Abstract

Gnotobiotic mice died 2 days after inoculation of a cytotoxigenic Clostridium difficile strain. Protection occurred when mice were previously inoculated with a strain of Escherichia coli or Bifidobacterium bifidum. Intestinal cytotoxin production was highly reduced in the surviving mice, whereas the C. difficile population level did not decrease to a great extent.

MeSH Terms

Adult Animals Antibiosis Bacteria/growth & development,isolation & purification Clostridium/growth & development,isolation & purification,metabolism Clostridium Infections/mortality Cytotoxins/biosynthesis Disease Models, Animal Feces/microbiology Germ-Free Life Humans Infant, Newborn Mice Species Specificity

Chemicals

Cytotoxins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Corthier G

Dubos F

Raibaud P

References (11)

11 references, click to expand

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Antagonism of toxigenic Clostridium difficile by nontoxigenic C. difficile.
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Article Info

Journal

Applied and environmental microbiology

Abbr.

Appl Environ Microbiol

ISSN

0099-2240

DOI

10.1128/aem.49.1.250-252.1985

Published

1985-01-00

Pages

250-2

Language

English

Region

United States

NLM ID

7605801

PMCID

PMC238383

Subset

External Links

PubMed source DOI: 10.1128/aem.49.1.250-252.1985 PMC Full Text View journal details

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Modulation of cytotoxin production by Clostridium difficile in the intestinal tracts of gnotobiotic mice inoculated with various human intestinal bacteria.

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