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PMID: 3981953 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effects of nicotine and its major metabolites on blood pressure in anaesthetized rats.

Klinische Wochenschrift ·Vol. 63 ·No. 2 ·1985-01-15 ·Pages 90-2

Dominiak P, Fuchs G, von Toth S, Grobecker H

Abstract

Blood pressure and heart rate in anaesthetized rats has been determined after i.v. injection of increasing doses of nicotine (NI) and its major metabolites, i.e. continine (CO), nornicotine (NOR), metanicotine (MN) and dihydrometanicotine (DMN). NI and MN elicited similar dose response curves, increasing blood pressure according to the dose injected. However, the dose response curve of MN was shifted to the right. Furthermore DMN caused similar pressor effects than MN and the pressor effects of NOR was even weaker. Only after injection of CO was a dose-dependent depressor effect observed and this was reversed after very high doses. CO also reduced heart rate in a dose-dependent manner, whereas NI and its other metabolites did not significantly change heart rate.

MeSH Terms
Animals Blood Pressure/drug effects Cotinine/pharmacology Dose-Response Relationship, Drug Male Nicotine/analogs & derivatives,pharmacology Rats Rats, Inbred Strains
Chemicals
3,4-dihydrometanicotine metanicotine Nicotine nornicotine Cotinine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dominiak P
Fuchs G
von Toth S
Grobecker H
References (8)
8 references, click to expand
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Article Info
Journal
Klinische Wochenschrift
Abbr.
Klin Wochenschr
ISSN
0023-2173
DOI
10.1007/BF01733074
Published
1985-01-15
Pages
90-2
Language
English
Region
Germany
NLM ID
2985205R
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01733074
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