Effect of puromycin on sugar transport in isolated rat adipocytes.

Biochimica et biophysica acta ·Vol. 817 ·No. 1 ·1985-07-11 ·Pages 187-9

Kubo K, Foley JE

Abstract

This study was performed to determine whether puromycin effects sugar transport into isolated rat adipocytes. Time-course and kinetic studies demonstrated that puromycin competitively inhibited 3-O-methylglucose transport. The data indicate that there is an acute effect of puromycin on sugar transport via competitive inhibition that is independent of the inhibition of protein synthesis.

MeSH Terms

3-O-Methylglucose Adipose Tissue/drug effects,metabolism Animals Biological Transport, Active/drug effects Carbon Radioisotopes Kinetics Male Methylglucosides/metabolism Methylglycosides/metabolism Puromycin/pharmacology Rats Rats, Inbred Strains

Chemicals

Carbon Radioisotopes Methylglucosides Methylglycosides 3-O-Methylglucose Puromycin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kubo K

Foley J E

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/0005-2736(85)90082-3

Published

1985-07-11

Pages

187-9

Language

English

Region

Netherlands

NLM ID

0217513

Subset

External Links

PubMed source DOI: 10.1016/0005-2736(85)90082-3

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Effect of puromycin on sugar transport in isolated rat adipocytes.

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