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PMID: 4006914 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transcripts from an aberrantly re-arranged human T-cell receptor beta-chain gene.

The EMBO journal ·Vol. 4 ·No. 5 ·1985-05-00 ·Pages 1211-5

Collins MK, Kissonerghis AM, Dunne MJ, Watson CJ, Rigby PW, Owen MJ

Abstract

A number of cDNA clones homologous to the human T-cell receptor beta-chain gene have been isolated from a library constructed from the human leukaemic cell line Jurkat. The nucleotide sequences of two of these clones demonstrate that Jurkat synthesizes an RNA, probably derived from an aberrantly rearranged C beta 1 gene, which cannot encode a functional beta-chain. This transcript contains a novel joining region and similar transcripts appear to be relatively abundant in several T-cell lines.

MeSH Terms
Base Sequence Humans Nucleic Acid Hybridization Receptors, Antigen, T-Cell/genetics Recombination, Genetic Transcription, Genetic
Chemicals
Receptors, Antigen, T-Cell
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Collins M K
Kissonerghis A M
Dunne M J
Watson C J
Rigby P W
Owen M J
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24 references, click to expand
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
1985-05-00
Pages
1211-5
Language
English
Region
England
NLM ID
8208664
PMCID
PMC554326
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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