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PMID: 4018453 Published · ppublish English Journal Article

Transcapillary colloid osmotic gradient, plasma volume and interstitial fluid volume in long-term type 1 (insulin-dependent) diabetes.

Diabetologia ·Vol. 28 ·No. 5 ·1985-05-00 ·Pages 269-73

Fauchald P, Norseth J, Jervell J

Abstract

Plasma and subcutaneous colloid osmotic pressure, transcapillary escape rate of albumin, plasma volume and extracellular fluid volume were measured in 10 long-term Type 1 (insulin-dependent) diabetic patients without clinical nephropathy. Interstitial colloid osmotic pressure was reduced compared with normal subjects (12.9 +/- 3.0 versus 15.8 +/- 2.7 mmHg, p less than 0.05) and the transcapillary colloid osmotic gradient increased (17.0 +/- 2.4 versus 12.8 +/- 2.7 mmHg, p less than 0.01). Plasma volume was in the normal range and interstitial fluid volume increased by approximately 21% compared with normal subjects (p less than 0.01). Transcapillary escape rate of albumin was significantly increased compared with normal subjects (8.9 +/- 1.9 versus 5.1 +/- 1.6% h, p less than 0.01). A negative correlation was found between the transcapillary colloid osmotic gradient and interstitial fluid volume (r = 0.6, 0.01 less than p less than 0.05). These results suggest that the increased small vessel permeability in long-term diabetes leads to wash-out of interstitial proteins and the resulting increased transcapillary colloid osmotic gradient tends to preserve the plasma volume and to limit the tendency to increased interstitial fluid volume.

MeSH Terms
Adult Blood Glucose/metabolism Blood Volume Capillary Permeability Colloids Creatinine/metabolism Diabetes Mellitus, Type 1/complications,physiopathology Diabetic Angiopathies/etiology,physiopathology Extracellular Space/metabolism Female Humans Male Middle Aged Osmotic Pressure Proteinuria Serum Albumin/metabolism
Chemicals
Blood Glucose Colloids Serum Albumin Creatinine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fauchald P
Norseth J
Jervell J
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27 references, click to expand
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Article Info
Journal
Diabetologia
Abbr.
Diabetologia
ISSN
0012-186X
DOI
10.1007/BF00271683
Published
1985-05-00
Pages
269-73
Language
English
Region
Germany
NLM ID
0006777
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00271683 View journal details
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