Correlations between the detection of e antigen or antibody and electron microscopic pattern of hepatitis B surface antigen (HBsAg) associated particles in the serum of HBsAg carriers.

Journal of clinical pathology ·Vol. 30 ·No. 3 ·1977-03-00 ·Pages 216-20

Trepo C, Bird RG, Zuckerman AJ

Abstract

The distribution of HBsAg associated particles, especially the presence of Dane particles, was studied by electron microscopy in coded sera of 68 chronic HBsAg carriers. Results were correlated with the detection of eAg or Ab and clinical diagnosis. Sera from haemodialysis and chronic hepatitis patients showed a high prevalence of e antigenaemia (9/13, 69-2% and 8/19, 42-1%) and Dane particles (11 and 16 respectively, 84%). By contrast, out of 36 chronic asymptomatic carriers of HBsAg, 28 (77-7%) were positive for e antibody but only 1 (2-7%) had eAg. Dane particles were found in 13/36 (36-1%). A statistically significant correlation was observed between the detection of eAg and the presence of Dane particles (94-4%) in the serum. However, Dane particles were still observed in 10/28 (35-7%) of anti-e positive sera. The data suggest that eAg may be linked to complete HB virions.

MeSH Terms

Antibodies/analysis Carrier State/immunology,microbiology Hepatitis B/immunology,microbiology Hepatitis B Antibodies/analysis Hepatitis B Antigens/analysis Hepatitis B Surface Antigens/isolation & purification Humans Microscopy, Electron Rh-Hr Blood-Group System

Chemicals

Antibodies Hepatitis B Antibodies Hepatitis B Antigens Hepatitis B Surface Antigens Rh-Hr Blood-Group System

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Trepo C

Bird R G

Zuckerman A J

References (24)

24 references, click to expand

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Article Info

Journal

Journal of clinical pathology

Abbr.

J Clin Pathol

ISSN

0021-9746

DOI

10.1136/jcp.30.3.216

Published

1977-03-00

Pages

216-20

Language

English

Region

England

NLM ID

0376601

PMCID

PMC476362

Subset

External Links

PubMed source DOI: 10.1136/jcp.30.3.216 PMC Full Text View journal details

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Correlations between the detection of e antigen or antibody and electron microscopic pattern of hepatitis B surface antigen (HBsAg) associated particles in the serum of HBsAg carriers.

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