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PMID: 4044518 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Mechanism of ethanol inhibition of fermentation in Zymomonas mobilis CP4.

Journal of bacteriology ·Vol. 164 ·No. 1 ·1985-10-00 ·Pages 173-80

Osman YA, Ingram LO

Abstract

Accumulation of alcohol during fermentation is accompanied by a progressive decrease in the rate of sugar conversion to ethanol. In this study, we provided evidence that inhibition of fermentation by ethanol can be attributed to an indirect effect of ethanol on the enzymes of glycolysis involving the plasma membrane. Ethanol decreased the effectiveness of the plasma membrane as a semipermeable barrier, allowing leakage of essential cofactors and coenzymes. This leakage of cofactors and coenzymes, coupled with possible additional leakage of intermediary metabolites en route to ethanol formation, is sufficient to explain the inhibitory effects of ethanol on fermentation in Zymomonas mobilis.

MeSH Terms
Biological Transport Ethanol/pharmacology Fermentation/drug effects Gram-Negative Bacteria/drug effects,metabolism Magnesium/metabolism,pharmacology Metals/pharmacology Nucleotides/pharmacology
Chemicals
Metals Nucleotides Ethanol Magnesium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Osman Y A
Ingram L O
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23 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.164.1.173-180.1985
Published
1985-10-00
Pages
173-80
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC214226
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.164.1.173-180.1985 PMC Full Text View journal details
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