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PMID: 404641 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Replication and expression of plasmids from Staphylococcus aureus in Bacillus subtilis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 4 ·1977-04-00 ·Pages 1680-2

Ehrlich SD

Abstract

One S. aureus plasmid coding for tetracycline resistance, pT127, and four plasmids (pC194, pC221, pC223, and pUB112) coding for chloramphenicol resistance have been introduced by transformation into B, subtilis. The plasmids replicate in--and confer antibiotic resistance upon--their new host. These experiments show that the potential for genetic exchange between diverse bacterial species is greater than has been commonly assumed.

MeSH Terms
Bacillus subtilis/drug effects,metabolism Chloramphenicol/pharmacology DNA Replication/drug effects Drug Resistance, Microbial Extrachromosomal Inheritance/drug effects Kanamycin/pharmacology Neomycin/pharmacology Plasmids/drug effects Recombination, Genetic Staphylococcus aureus/drug effects Streptomycin/pharmacology Tetracycline/pharmacology Transformation, Genetic
Chemicals
Kanamycin Chloramphenicol Tetracycline Neomycin Streptomycin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ehrlich S D
References (7)
7 references, click to expand
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    Proc Natl Acad Sci U S A. 1976 Nov;73(11):4145-9 PMID: 825858
  2. Plasmids in Pseudomonas.
    Annu Rev Genet. 1976;10:7-30 PMID: 797315
  3. Studies on plasmid replication. I. Plasmid incompatibility and establishment in Staphylococcus aureus.
    J Mol Biol. 1972 Jul 21;68(2):285-302 PMID: 4262657
  4. Physical heterogeneity among Bacillus subtilis deoxyribonucleic acid molecules carrying particular genetic markers.
    J Bacteriol. 1969 Jun;98(3):1239-47 PMID: 4977986
  5. Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.
    Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66 PMID: 4894690
  6. Electrophoretic separation of Bacillus subtilis genes.
    Proc Natl Acad Sci U S A. 1975 Jun;72(6):2207-11 PMID: 806078
  7. Plasmid-protein relaxation complexes in Staphylococcus aureus.
    J Bacteriol. 1976 Sep;127(3):1177-87 PMID: 956124
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.4.1680
Published
1977-04-00
Pages
1680-2
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC430856
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.4.1680 PMC Full Text View journal details
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