Home LiteratureArticle Details
PMID: 404708 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Covalent labeling of the tetrodotoxin receptor in excitable membranes.

Science (New York, N.Y.) ·Vol. 196 ·No. 4292 ·1977-05-20 ·Pages 883-5

Guillory RJ, Rayner MD, D'Arrigo JS

Abstract

A photoaffinity labeling technique is described by which a tetrodotoxin analog is covalently bound to receptor sites associated with the sodium pores of excitable membranes. The biological activity of the toxin analog is retained after the covalent binding reaction.

MeSH Terms
Affinity Labels/chemical synthesis,pharmacology Animals Bufo marinus Membrane Potentials/drug effects Muscles/metabolism Photochemistry Receptors, Drug/metabolism Tetrodotoxin/analogs & derivatives,metabolism,pharmacology
Chemicals
Affinity Labels Receptors, Drug Tetrodotoxin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Guillory R J
Rayner M D
D'Arrigo J S
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.404708
Published
1977-05-20
Pages
883-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
External Links
PubMed source DOI: 10.1126/science.404708 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2