Home LiteratureArticle Details
PMID: 4056048 Published · ppublish English Journal Article

Myocardial reperfusion: a double-edged sword?

The Journal of clinical investigation ·Vol. 76 ·No. 5 ·1985-11-00 ·Pages 1713-9

Braunwald E, Kloner RA

Abstract

暂无摘要

MeSH Terms
Calcium/adverse effects Coronary Circulation Free Radicals Hemorrhage/etiology Humans Myocardial Infarction/pathology,therapy Necrosis Oxygen/adverse effects Water-Electrolyte Balance
Chemicals
Free Radicals Oxygen Calcium
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Braunwald E
Kloner R A
References (58)
58 references, click to expand
  1. Prolonged derangements of canine myocardial purine metabolism after a brief coronary artery occlusion not associated with anatomic evidence of necrosis.
    Proc Natl Acad Sci U S A. 1980 Sep;77(9):5471-5 PMID: 6933566
  2. The "no-reflow" phenomenon after temporary coronary occlusion in the dog.
    J Clin Invest. 1974 Dec;54(6):1496-508 PMID: 4140198
  3. Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.
    Circ Res. 1984 Mar;54(3):277-85 PMID: 6697450
  4. LOW INCIDENCE OF CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION. A RESTUDY BY SERIAL BLOCK TECHNIQUE.
    Arch Pathol. 1964 Oct;78:432-45 PMID: 14184673
  5. Low calcium reperfusion of ischemic myocardium.
    J Mol Cell Cardiol. 1983 Apr;15(4):251-60 PMID: 6876182
  6. Xanthine oxidase as a source of free radical damage in myocardial ischemia.
    J Mol Cell Cardiol. 1985 Feb;17(2):145-52 PMID: 3839024
  7. Superoxide dismutase plus catalase enhances the efficacy of hypothermic cardioplegia to protect the globally ischemic, reperfused heart.
    J Thorac Cardiovasc Surg. 1982 Jun;83(6):830-9 PMID: 7087509
  8. The role of lipid peroxidation in pathogenesis of ischemic damage and the antioxidant protection of the heart.
    Basic Res Cardiol. 1982 Sep-Oct;77(5):465-85 PMID: 7181828
  9. Deleterious effects due to hemorrhage after myocardial reperfusion.
    Am J Cardiol. 1974 Jan;33(1):82-6 PMID: 4543365
  10. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog.
    Am J Pathol. 1983 Apr;111(1):98-111 PMID: 6837725
  11. Thrombolytic therapy. A new strategy for the treatment of acute myocardial infarction (2).
    N Engl J Med. 1984 Sep 20;311(12):770-6 PMID: 6236369
  12. Functional improvement of jeopardized myocardium following intracoronary streptokinase infusion in acute myocardial infarction.
    J Clin Invest. 1983 Jul;72(1):84-95 PMID: 6874955
  13. Role of oxygen radicals in cardiac injury due to reoxygenation.
    J Mol Cell Cardiol. 1984 May;16(5):459-70 PMID: 6330372
  14. Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.
    Am J Pathol. 1982 Jun;107(3):395-418 PMID: 6282132
  15. Molecular oxygen: friend and foe. The role of the oxygen free radical system in the calcium paradox, the oxygen paradox and ischemia/reperfusion injury.
    J Mol Cell Cardiol. 1984 Nov;16(11):969-85 PMID: 6394765
  16. Effect of reperfusion late in the phase of reversible ischemic injury. Changes in cell volume, electrolytes, metabolites, and ultrastructure.
    Circ Res. 1985 Feb;56(2):262-78 PMID: 3971504
  17. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction.
    N Engl J Med. 1980 Oct 16;303(16):897-902 PMID: 7412821
  18. Early membrane damage during coronary reperfusion in dogs. Detection by radiolabeled anticardiac myosin (Fab')2.
    J Clin Invest. 1983 Aug;72(2):535-44 PMID: 6223942
  19. Proton and free oxygen radical interaction with the calcium transport system of cardiac sarcoplasmic reticulum.
    J Mol Cell Cardiol. 1981 Aug;13(8):767-72 PMID: 6267305
  20. The aggressive treatment of acute myocardial infarction.
    Circulation. 1985 Jun;71(6):1087-92 PMID: 3158451
  21. The protective effect of hyperosmotic mannitol in myocardial ischemia and necrosis.
    Circulation. 1976 Oct;54(4):603-15 PMID: 963849
  22. Reduction of infarct size with intracoronary perfluorochemical in a canine preparation of reperfusion.
    Circulation. 1985 May;71(5):1060-8 PMID: 3986976
  23. The stunned myocardium: prolonged, postischemic ventricular dysfunction.
    Circulation. 1982 Dec;66(6):1146-9 PMID: 6754130
  24. Reperfusion of the ischemic myocardium.
    J Mol Cell Cardiol. 1977 Aug;9(8):605-16 PMID: 903971
  25. Reperfusion-induced arrhythmias: mechanisms and prevention.
    J Mol Cell Cardiol. 1984 Jun;16(6):497-518 PMID: 6146724
  26. A flow- and time-dependent index of ischemic injury after experimental coronary occlusion and reperfusion.
    Proc Natl Acad Sci U S A. 1983 Sep;80(18):5784-8 PMID: 6577455
  27. Myocardial necrosis induced by temporary occlusion of a coronary artery in the dog.
    Arch Pathol. 1960 Jul;70:68-78 PMID: 14407094
  28. Response of reperfusion-salvaged, stunned myocardium to inotropic stimulation.
    Am Heart J. 1984 Jan;107(1):13-9 PMID: 6691220
  29. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow.
    Lab Invest. 1979 Jun;40(6):633-44 PMID: 449273
  30. Myocardial alterations due to free-radical generation.
    Am J Physiol. 1984 Jun;246(6 Pt 2):H776-83 PMID: 6331179
  31. The effect of streptokinase on intramyocardial hemorrhage, infarct size, and the no-reflow phenomenon during coronary reperfusion.
    Circulation. 1984 Sep;70(3):513-21 PMID: 6744555
  32. Role of free radicals in catecholamine-induced cardiomyopathy.
    Can J Physiol Pharmacol. 1982 Nov;60(11):1390-7 PMID: 7151008
  33. EXPERIMENTAL ACUTE MYOCARDIAL INFARCTION; HISTOLOGIC AND HISTOCHEMICAL STUDIES OF EARLY MYOCARDIAL INFARCTS INDUCED BY TEMPORARY OR PERMANENT OCCLUSION OF A CORONARY ARTERY.
    Lab Invest. 1964 Dec;13:1491-503 PMID: 14252312
  34. Regulation of cellular volume.
    Physiol Rev. 1977 Jul;57(3):510-73 PMID: 142257
  35. Prolonged depletion of ATP and of the adenine nucleotide pool due to delayed resynthesis of adenine nucleotides following reversible myocardial ischemic injury in dogs.
    J Mol Cell Cardiol. 1981 Feb;13(2):229-39 PMID: 7265245
  36. An approach to free radicals in medicine and biology.
    Acta Physiol Scand Suppl. 1980;492:153-68 PMID: 6261528
  37. Myocardial cell volume and coronary resistance during diminished coronary perfusion.
    Am J Physiol. 1984 Sep;247(3 Pt 2):H467-77 PMID: 6433726
  38. Coronary artery reperfusion. II. Reduction of myocardial infarct size at 1 week after the coronary occlusion.
    J Clin Invest. 1972 Oct;51(10):2717-23 PMID: 5056664
  39. Lethal myocardial ischemic injury.
    Am J Pathol. 1981 Feb;102(2):241-55 PMID: 7008621
  40. Time course of functional and biochemical recovery of myocardium salvaged by reperfusion.
    J Am Coll Cardiol. 1983 Apr;1(4):1047-55 PMID: 6833644
  41. Effect of coronary reperfusion on myocardial hemorrhage and infarct healing.
    Am J Cardiol. 1983 Sep 1;52(5):610-4 PMID: 6613887
  42. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.
    Circulation. 1977 Nov;56(5):786-94 PMID: 912839
  43. Ultrastructural evidence of microvascular damage and myocardial cell injury after coronary artery occlusion: which comes first?
    Circulation. 1980 Nov;62(5):945-52 PMID: 7418179
  44. Oxygen-derived free radicals in postischemic tissue injury.
    N Engl J Med. 1985 Jan 17;312(3):159-63 PMID: 2981404
  45. Tissue osmolality, cell swelling, and reperfusion in acute regional myocardial ischemia in the isolated porcine heart.
    Circ Res. 1981 Aug;49(2):364-81 PMID: 7249273
  46. The free radical pathology and the microcirculation in the major central nervous system disorders.
    Acta Physiol Scand Suppl. 1980;492:91-119 PMID: 6939309
  47. Hemorrhagic myocardial infarction after streptokinase treatment for acute coronary thrombosis.
    Arch Pathol Lab Med. 1984 Feb;108(2):121-4 PMID: 6546493
  48. Reduction of the extent of ischemic myocardial injury by neutrophil depletion in the dog.
    Circulation. 1983 May;67(5):1016-23 PMID: 6831665
  49. Coronary reperfusion for the treatment of acute myocardial infarction: postischemic ventricular dysfunction.
    Cardiology. 1983;70(5):233-46 PMID: 6365310
  50. The biology of oxygen radicals.
    Science. 1978 Sep 8;201(4359):875-80 PMID: 210504
  51. The oxygen paradox and the calcium paradox: two facets of the same problem?
    J Mol Cell Cardiol. 1978 Jul;10(7):641-68 PMID: 691070
  52. Effects of propranolol on myocardial infarct size with and without coronary artery reperfusion in the dog.
    Cardiovasc Res. 1981 Jul;15(7):411-20 PMID: 7307024
  53. Superoxide radicals in feline intestinal ischemia.
    Gastroenterology. 1981 Jul;81(1):22-9 PMID: 6263743
  54. Coronary thrombolysis with recombinant human tissue-type plasminogen activator: a prospective, randomized, placebo-controlled trial.
    Circulation. 1984 Dec;70(6):1012-7 PMID: 6388898
  55. Enhancement of salvage of reperfused myocardium by early beta-adrenergic blockade (timolol).
    J Am Coll Cardiol. 1984 Jun;3(6):1438-43 PMID: 6715704
  56. Hydrogen peroxide and hydroxyl radical mediation of activated leukocyte depression of cardiac sarcoplasmic reticulum. Participation of the cyclooxygenase pathway.
    Circ Res. 1983 Nov;53(5):584-91 PMID: 6138170
  57. Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.
    Circ Shock. 1981;8(3):273-82 PMID: 7249259
  58. Cerebral ischemia. III. Vascular changes.
    Am J Pathol. 1968 Feb;52(2):455-76 PMID: 5635862
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI112160
Published
1985-11-00
Pages
1713-9
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC424191
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI112160 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2