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PMID: 4057359 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic reassortment of mammalian reoviruses in mice.

Journal of virology ·Vol. 56 ·No. 2 ·1985-11-00 ·Pages 613-6

Wenske EA, Chanock SJ, Krata L, Fields BN

Abstract

Reassortments between type 1 (Lang) and type 3 (Dearing) reoviruses were isolated from suckling mice infected perorally with an inoculum containing both type 1 and type 3 viruses. A total of five distinct reassortants (designated as E1 through E5) were isolated from animals during the course of the experiment. Two reassortants (E1 and E2) represented the majority of the reassortants isolated. The majority of genes of types E1 and E2 were derived from type 1 (Lang). However, E1 had an M2 gene and an S1 gene derived from type 3 (Dearing), while E2 had M2 and S2 genes derived from type 3 (Dearing). Thus, nonrandom reassortment between mammalian reoviruses can be demonstrated in vivo.

MeSH Terms
Animals Mammalian orthoreovirus 3/genetics Mice RNA, Double-Stranded/genetics RNA, Viral/genetics Recombination, Genetic Reoviridae/genetics
Chemicals
RNA, Double-Stranded RNA, Viral
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wenske E A
Chanock S J
Krata L
Fields B N
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20 references, click to expand
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.56.2.613-616.1985
Published
1985-11-00
Pages
613-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC252619
Subset
IM
Grants
NINDS NIH HHS · 2P01 NS1 6998 · United States
PHS HHS · 5 R01 A1 13178 · United States
NCI NIH HHS · 5T32 CA0 9031 · United States
External Links
PubMed source DOI: 10.1128/JVI.56.2.613-616.1985 PMC Full Text View journal details
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