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PMID: 406348 Published · ppublish English Journal Article

Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.

The Journal of experimental medicine ·Vol. 146 ·No. 1 ·1977-07-01 ·Pages 59-73

Mosier DE, Mathieson BJ, Campbell PS

Abstract

Neonatal suppressor T cells were isolated from the thymuses of 10- to 14-day old BDF mice infected at birth with mouse thymic virus. Such cells were enriched for suppressive activity directed against antibody formation by adult B cells and represented a relatively homogenous population of outer cortical cells. Their surface antigen phenotype was found to be: Ly 1+, Ly 2+, TL+, Thy 1+, and H-2+. The cells were larger and contained more DNA than thymocytes from age-matched controls. These findings identify neonatal suppressor T cells as a unique subpopulation separate from most inducible suppressor cells in the adult mouse. The mechanism of action of neonatal suppressor T cells seems to be a reduction in the number of B cells initially triggered by antigen.

MeSH Terms
Animals Animals, Newborn Antibody Formation Antibody-Producing Cells Cytotoxicity Tests, Immunologic Female Ficoll/immunology Hemolytic Plaque Technique Histocompatibility Antigens Immune Sera Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Inbred DBA Mitogens/pharmacology Phenotype Spleen/cytology Suppression, Genetic T-Lymphocytes/immunology Thymus Gland/cytology Trinitrobenzenes/immunology Viruses, Unclassified
Chemicals
Histocompatibility Antigens Immune Sera Mitogens Trinitrobenzenes Ficoll
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Mosier D E
Mathieson B J
Campbell P S
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31 references, click to expand
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.146.1.59
Published
1977-07-01
Pages
59-73
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2180724
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.146.1.59 PMC Full Text View journal details
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