Home LiteratureArticle Details

PMID: 4073865 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Comparative in vitro activities of MDL 473, rifampin, and ansamycin against Mycobacterium intracellulare.

Antimicrobial agents and chemotherapy ·Vol. 28 ·No. 3 ·1985-09-00 ·Pages 440-1

Cynamon MH

Abstract

The susceptibilities of 20 clinical isolates of Mycobacterium intracellulare to rifampin, MDL 473, and ansamycin were determined by broth and agar dilution methods. Ansamycin was more active than MDL 473, which in turn was usually more active than rifampin by either method. The MICs for 90% of the strains tested by agar dilution were 1, 2, and 4 micrograms of ansamycin, MDL 473, and rifampin per ml, respectively.

MeSH Terms

Anti-Bacterial Agents In Vitro Techniques Lactams, Macrocyclic Microbial Sensitivity Tests Mycobacterium/drug effects Rifampin/analogs & derivatives,pharmacology

Chemicals

Anti-Bacterial Agents Lactams, Macrocyclic Rifampin rifapentine

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cynamon M H

References (13)

13 references, click to expand

Rifampin: in vitro effect on atypical mycobacteria.
Am Rev Respir Dis. 1971 Aug;104(2):272-4 PMID: 5558997
Effect of temperature on the rate of the transparent to opaque colony type transition in Mycobacterium avium.
Antimicrob Agents Chemother. 1976 Jan;9(1):113-9 PMID: 1259385
Permeability barrier to rifampin in mycobacteria.
Antimicrob Agents Chemother. 1977 May;11(5):773-9 PMID: 879732
The pleiotropic effect of spontaneous single-step variant production in Mycobacterium intracellulare.
Scand J Respir Dis. 1978 Apr;59(2):91-100 PMID: 356253
Nontuberculous mycobacteria and associated diseases.
Am Rev Respir Dis. 1979 Jan;119(1):107-59 PMID: 369415
Pulmonary mycobacterial infections due to Mycobacterium intracellulare-avium complex. Clinical features and course in 100 consecutive cases.
Chest. 1979 Feb;75(2):115-9 PMID: 421545
In vitro activity of amoxicillin in combination with clavulanic acid against Mycobacterium tuberculosis.
Antimicrob Agents Chemother. 1983 Sep;24(3):429-31 PMID: 6416162
Multiple drug resistance in Mycobacterium avium: is the wall architecture responsible for exclusion of antimicrobial agents?
Antimicrob Agents Chemother. 1981 Nov;20(5):666-77 PMID: 6798925
Comparison of the sensitivity of mycobacteria to the cyclopentyl rifamycin DL473 and rifampicin.
J Antimicrob Chemother. 1982 Aug;10(2):147-50 PMID: 7118764
In vitro susceptibility of Mycobacterium avium complex and Mycobacterium tuberculosis strains to a spiro-piperidyl rifamycin.
Am Rev Respir Dis. 1982 Sep;126(3):586-7 PMID: 6289711
Mycobacterium avium-intracellulare: a cause of disseminated life-threatening infection in homosexuals and drug abusers.
Ann Intern Med. 1982 Oct;97(4):539-46 PMID: 6289714
In vitro synergistic activity of ethambutol, isoniazid, kanamycin, rifampin, and streptomycin against Mycobacterium avium-intracellulare complex.
Antimicrob Agents Chemother. 1982 Jul;22(1):148-50 PMID: 7125626
Long-term results of medical treatment in Mycobacterium intracellulare infection.
Am J Med. 1979 Sep;67(3):449-53 PMID: 474589

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.28.3.440

Published

1985-09-00

Pages

440-1

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC180270

Subset

External Links

PubMed source DOI: 10.1128/AAC.28.3.440 PMC Full Text View journal details

Analysis Services

Comparative in vitro activities of MDL 473, rifampin, and ansamycin against Mycobacterium intracellulare.

Contact

WeChat Official Account