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PMID: 407576 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Location and structural significance of the oligosaccharides in human Ig-A1 and IgA2 immunoglobulins.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 6 ·1977-06-00 ·Pages 2301-5

Toraño A, Tsuzukida Y, Liu YS, Putnam FW

Abstract

The location, number, and kinds of oligosaccharides in human IgA1 and IgA2 immunoglobulins have been determined by amino acid sequence analysis of the alpha heavy chains. Both A2m allotypes of the alpha2 chain of IgA2 have two GlcN oligosaccharides that are absent in the alpha1 chain, but they lack GalN. The A2m(2) allotype has a fifth GlcN oligosaccharide. The alpha chains of IgA proteins also have subclass-specific and allotype-specific differences in amino acid sequence. Although other classes of human immunoglobulins differ in the number and kind of oligosaccharides, the sites are often homologous and are related to the immunoglobulin domain structure. Evolutionary preservation of the tripeptide acceptor sequence for GlcN probably indicates both a structural and biological role for carbohydrate.

MeSH Terms
Amino Acid Sequence Carbohydrates/analysis Humans Immunoglobulin A Immunoglobulin Heavy Chains Immunoglobulin Light Chains Oligosaccharides/analysis
Chemicals
Carbohydrates Immunoglobulin A Immunoglobulin Heavy Chains Immunoglobulin Light Chains Oligosaccharides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Toraño A
Tsuzukida Y
Liu Y S
Putnam F W
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.74.6.2301
Published
1977-06-00
Pages
2301-5
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432158
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.74.6.2301 PMC Full Text View journal details
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