Measles immunoglobulins in subacute sclerosing panencephalitis.

British medical journal ·Vol. 1 ·No. 5739 ·1971-01-02 ·Pages 23-5

Connolly JH, Haire M, Hadden DS

Abstract

Normal responses of measles specific immunoglobulins M and G (IgM and IgG) were defined in 10 children with measles. Abnormal responses of measles IgM and IgG were found in both sera and cerebrospinal fluids from three cases of subacute sclerosing panencephalitis. In two patients the serum titres of measles IgM and IgG were abnormally high. The measles IgM was present during prolonged illnesses in serum and cerebrospinal fluid, which suggested a correlation with the known persistence of measles virus antigen in the brain of the three patients. It was concluded that both measles IgM and IgG may be produced within the central nervous system in subacute sclerosing panencephalitis.

MeSH Terms

Antigens/analysis Brain/immunology Child Child, Preschool Humans Immunoglobulin G/analysis,cerebrospinal fluid Immunoglobulin M/analysis,cerebrospinal fluid Immunoglobulins/analysis,cerebrospinal fluid Measles/immunology Measles virus Subacute Sclerosing Panencephalitis/diagnosis,immunology gamma-Globulins/analysis

Chemicals

Antigens Immunoglobulin G Immunoglobulin M Immunoglobulins gamma-Globulins

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Connolly J H

Haire M

Hadden D S

References (13)

13 references, click to expand

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Article Info

Journal

British medical journal

Abbr.

Br Med J

ISSN

0007-1447

DOI

10.1136/bmj.1.5739.23

Published

1971-01-02

Pages

23-5

Language

English

Region

England

NLM ID

0372673

PMCID

PMC1794767

Subset

External Links

PubMed source DOI: 10.1136/bmj.1.5739.23 PMC Full Text

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