Induction of spectrin in erythroleukemic cells transformed by Friend virus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 9 ·1977-09-00 ·Pages 3898-902

Eisen H, Bach R, Emery R

Abstract

The presence and accumulation in murine erythroleukemic cells transformed by Friend virus of the erythrocyte membrane-associated protein spectrin has been investigated. Spectrin was present in the uninduced cells and was induced 10- to 20-fold in dimethyl sulfoxide-treated differentiating cells. The intracellular concentration of spectrin reached a peak on the third day of dimethyl sulfoxide treatment, after which it fell to levels found in mouse erythrocytes. We also found that the small subunit of spectrin was phosphorylated in the cells.

MeSH Terms

Animals Cell Differentiation/drug effects Cell Line Cell Transformation, Viral Dimethyl Sulfoxide/pharmacology Friend murine leukemia virus Leukemia, Erythroblastic, Acute/metabolism Mast-Cell Sarcoma/metabolism Membrane Proteins/biosynthesis Mice Spectrin/biosynthesis

Chemicals

Membrane Proteins Spectrin Dimethyl Sulfoxide

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Eisen H

Bach R

Emery R

References (25)

25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.9.3898

Published

1977-09-00

Pages

3898-902

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431776

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.9.3898 PMC Full Text View journal details

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Induction of spectrin in erythroleukemic cells transformed by Friend virus.

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