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PMID: 4105490
Published · ppublish
English
Journal Article
Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release.
Abstract
Extracellular histamine stimulates accumulation of adenosine 3',5'-monophosphate in human leukocytes and prevents antigenic release of histamine from cells of allergic donors. Both effects occur at histamine concentrations that can be achieved by antigenic release of the amine in vitro.
MeSH Terms
Adenine/metabolism
Adenine Nucleotides/metabolism
Adenosine Monophosphate/metabolism
Antigens
Depression, Chemical
Histamine/pharmacology
Histamine Release/drug effects
Humans
Hypersensitivity/metabolism
In Vitro Techniques
Leukocytes/drug effects,metabolism
Plants
Stimulation, Chemical
Tritium
Chemicals
Adenine Nucleotides
Antigens
Tritium
Adenosine Monophosphate
Histamine
Adenine
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
Published
1971-08-20
Pages
743-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
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