Home LiteratureArticle Details
PMID: 4109599 Published · ppublish English Journal Article

Ultrastructure of the human complement component, Clq (negative staining-glutamine synthetase-biologically active Clq).

Shelton E, Yonemasu K, Stroud RM

Abstract

The human complement component, Clq, is a fragile molecule of delicate structure consisting of three distinct parts, a central subunit, connecting strands, and terminal subunits. Each terminal subunit is further subdivided into a large and a small subunit, and the central subunit appears to be divided into two equal parts. In the intact molecule, six connecting strands link six terminal subunits by their larger subdivision to the central subunit. The overall diameter of the molecule when viewed from the "top" is about 35 nm (350 A).

MeSH Terms
Centrifugation Complement System Proteins/analysis,isolation & purification Escherichia coli/enzymology Glutamate-Ammonia Ligase Humans Immune Sera Immunodiffusion Immunoglobulins Microscopy, Electron Protein Conformation Staining and Labeling
Chemicals
Immune Sera Immunoglobulins Complement System Proteins Glutamate-Ammonia Ligase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Shelton E
Yonemasu K
Stroud R M
References (7)
7 references, click to expand
  1. The ultrastructure of normal and pathological IgM immunoglobulins.
    J Exp Med. 1968 Mar 1;127(3):399-410 PMID: 4169962
  2. Regulation of glutamine synthetase. XII. Electron microscopy of the enzyme from Escherichia coli.
    Biochemistry. 1968 Jun;7(6):2143-52 PMID: 4873173
  3. Chemistry and reaction mechanisms of complement.
    Adv Immunol. 1968;8:1-80 PMID: 4174135
  4. Ultrastructure of the gamma M immunoglobulin-molecule.
    J Mol Biol. 1970 Feb 14;47(3):595-7 PMID: 5418172
  5. The ultrastructure of human C1q.
    Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(2):260-2 PMID: 5275083
  6. Clq: rapid purification method for preparation of monospecific antisera and for biochemical studies.
    J Immunol. 1971 Feb;106(2):304-13 PMID: 5545135
  7. Chemical studies of Clq; a modulator of immunoglobulin biology.
    Biochem Biophys Res Commun. 1971 Jun 18;43(6):1388-94 PMID: 4328047
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
1972-01-00
Pages
65-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC427545
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]