Absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2.

Journal of virology ·Vol. 9 ·No. 6 ·1972-06-00 ·Pages 1059-63

Rapp F, Conner R, Glaser R, Duff R

Abstract

Hamster cells which transformed after exposure to herpes simplex virus type 2 previously irradiated with ultraviolet light were tested for the presence of hamster leukosis viruses or their virus-specific antigens. Three techniques that were used did not detect the presence of either hamster C-type particles or antigens commonly associated with such structures. The implication of these findings to current concepts of virus oncology is discussed.

MeSH Terms

Animals Antigens, Viral/isolation & purification Bromodeoxyuridine Cell Line/immunology,microbiology Cell Nucleus/microbiology Cell Transformation, Neoplastic Centrifugation, Density Gradient Cricetinae Cytoplasm/microbiology Fibroblasts Fluorescent Antibody Technique Inclusion Bodies, Viral Microscopy, Electron RNA Viruses/immunology,isolation & purification Radiation Effects Retroviridae/immunology,isolation & purification Serotyping Simplexvirus/growth & development,radiation effects Staining and Labeling Tritium Ultraviolet Rays Uridine

Chemicals

Antigens, Viral Tritium Bromodeoxyuridine Uridine

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Rapp F

Conner R

Glaser R

Duff R

References (12)

12 references, click to expand

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Localization of avian tumor virus group-specific antigen in cell and virus.
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Oncogenes of RNA tumor viruses as determinants of cancer.
Proc Natl Acad Sci U S A. 1969 Nov;64(3):1087-94 PMID: 5264139
Serological identification of hamster oncornaviruses.
Nat New Biol. 1971 Apr 28;230(17):282-4 PMID: 4325141
Oncogenic transformation of hamster cells after exposure to herpes simplex virus type 2.
Nat New Biol. 1971 Sep 8;233(36):48-50 PMID: 4329350
Murine leukemia virus: high-frequency activation in vitro by 5-iododeoxyuridine and 5-bromodeoxyuridine.
Science. 1971 Oct 8;174(4005):155-6 PMID: 4330367
Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells.
Science. 1971 Oct 8;174(4005):157-9 PMID: 5119627
Properties of hamster embryo fibroblasts transformed in vitro after exposure to ultraviolet-irradiated herpes simplex virus type 2.
J Virol. 1971 Oct;8(4):469-77 PMID: 4108570
DNA synthesis by RNA-containing tumor viruses.
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1034-41 PMID: 4331715
Activation and isolation of hamster-specific C-type RNA viruses from tumors induced by cell cultures transformed by chemical carcinogens.
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2386-90 PMID: 5289874
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Article Info

Journal

Journal of virology

Abbr.

J Virol

ISSN

0022-538X

DOI

10.1128/JVI.9.6.1059-1063.1972

Published

1972-06-00

Pages

1059-63

Language

English

Region

United States

NLM ID

0113724

PMCID

PMC356413

Subset

External Links

PubMed source DOI: 10.1128/JVI.9.6.1059-1063.1972 PMC Full Text View journal details

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Absence of leukosis virus markers in hamster cells transformed by herpes simplex virus type 2.

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