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PMID: 411457 Published · ppublish English Journal Article

Vascular clearance of venezuelan equine encephalomyelitis viruses as a correlate to virulence for rhesus monkeys.

Archives of virology ·Vol. 55 ·No. 1-2 ·1977-00-00 ·Pages 161-4

Jahrling PB, Hilmas DE, Heard CD

Abstract

The epizootic Trinidad donkey strain of Venezuelan equime encephalomyelitis virus (VEE) was cleared slowly from the circulation of rhesus monkeys following intravenous inoculation, while the live, attenuated vaccine strain, TC-83, was cleared rapidly. The efficent clearance of TC-83 vaccine may be a factor in the lower viremia and benign course of TC-83 virus infection in rhesus monkeys.

MeSH Terms
Animals Blood/microbiology Encephalitis Virus, Venezuelan Equine/isolation & purification,pathogenicity Haplorhini Macaca mulatta Vaccines, Attenuated Viral Vaccines Virulence
Chemicals
Vaccines, Attenuated Viral Vaccines
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Jahrling P B
Hilmas D E
Heard C D
References (10)
10 references, click to expand
  1. The Rhesus monkey as a model for the study of infectious disease.
    Am J Phys Anthropol. 1973 Mar;38(2):501-4 PMID: 4144049
  2. Experimental studies of rhesus monkeys infected with epizootic and enzootic subtypes of Venezuelan equine encephalitis virus.
    J Infect Dis. 1974 Feb;129(2):194-200 PMID: 4204239
  3. Response of sublethally irradiated monkeys to a replicating viral antigen.
    Infect Immun. 1975 Sep;12(3):592-601 PMID: 809358
  4. Growth curves and clearance rates of virulent and benign Venezuelan encephalitis viruses in hamsters.
    Infect Immun. 1973 Sep;8(3):456-62 PMID: 4125784
  5. USE OF AN ATTENUATED STRAIN OF VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS FOR IMMUNIZATION IN MAN.
    Am J Trop Med Hyg. 1963 Jul;12:597-603 PMID: 14044773
  6. The comparative pathology of experimental Venezuelan equine encephalomyelitis infection in different animal hosts.
    J Infect Dis. 1962 Jan-Feb;110:80-97 PMID: 13899188
  7. The growth of Venezuelan equine encephalomyelitis virus in various tissue cultures.
    Am J Hyg. 1959 Jul;70(1):21-7 PMID: 13670164
  8. The comparative pathology of Venezuelan equine encephalomyelitis.
    J Infect Dis. 1956 Jan-Feb;98(1):55-66 PMID: 13295626
  9. Selective clearance of a benign clone of Venezuelan equine encephalitis virus from hamster plasma by hepatic reticuloendothelial cells.
    J Infect Dis. 1975 Dec;132(6):667-76 PMID: 1202111
  10. Experimental infection of horses with enzootic and epizootic strains of Venezuelan equine encephalomyelitis virus.
    J Infect Dis. 1973 Sep;128(3):271-82 PMID: 4728689
Article Info
Journal
Archives of virology
Abbr.
Arch Virol
ISSN
0304-8608
Published
1977-00-00
Pages
161-4
Language
English
Region
Austria
NLM ID
7506870
Subset
IM
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