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PMID: 4114856 Published · ppublish English Journal Article

Induction of immunological tolerance to soluble histocompatibility-2 antigens of mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 69 ·No. 7 ·1972-07-00 ·Pages 1858-62

Law LW, Appella E, Strober S, Wright PW, Fischetti T

Abstract

Immunological tolerance to a soluble, partially purified fraction of histocompatibility (H)-2(a) antigen was induced in B10.D2 strain mice. The fraction used was obtained after chromatography on a Sephadex G-150 column. Tolerance of humoral-antibody formation (cytotoxins and hemagglutinins) was observed in mice injected with soluble antigen since birth, but cell-mediated immunity, as measured by skin graft survival, remained intact. Tolerance was shown to be specific for H-2(a) antigens, since treated mice produced a regular humoral-antibody response to H-2(b) antigens. These findings, along with previous observations of the immunogenic and enhancing properties of our partially purified fraction, suggest that the solubilized antigen contains all the major determinants of H-2(a) antigens expressed on lymphoid-cell surfaces.

MeSH Terms
Animals Antibodies/analysis Antibody Formation Antigens/isolation & purification Chromatography, Gel Chromium Isotopes Epitopes Female Graft Rejection Hemagglutination Tests Histocompatibility Immune Tolerance Mice Mice, Inbred Strains Skin Transplantation Spleen/cytology,immunology Transplantation, Homologous
Chemicals
Antibodies Antigens Chromium Isotopes Epitopes
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Law L W
Appella E
Strober S
Wright P W
Fischetti T
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22 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.69.7.1858
Published
1972-07-00
Pages
1858-62
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC426819
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.69.7.1858 PMC Full Text View journal details
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