Role of the mast cell in the pulmonary pressor response to hypoxia.

The Journal of clinical investigation ·Vol. 51 ·No. 12 ·1972-12-00 ·Pages 3154-62

Haas F, Bergofsky EH

Abstract

This study investigated the role of the mast cell in the pulmonary arterial pressor response to hypoxia. We found that pulmonary arteries 50-500 mu in diameter have a predictable distribution of perivascular mast cells; that such pulmonary mast cells are degranulated in vivo during alveolar hypoxia; that hypoxia releases histamine from mast cells isolated from the peritoneal cavity without apparent injury to the cells; and that histamine is released from the lung of intact guinea pigs during alveolar hypoxia, with the rise in pulmonary vascular resistance during this period proportional to the amount of histamine released. These data point to the perivascular pulmonary mast cell in the rat and guinea pig as an important structure in the mediation of the pulmonary pressor response to hypoxia, even though the responsible humoral vasoconstrictor released from such a cell may not be histamine, or histamine alone.

MeSH Terms

Animals Blood Pressure Carbon Isotopes Constriction Cytoplasmic Granules Disease Models, Animal Guinea Pigs Histamine Release Hypoxia/physiopathology Lung/metabolism Mast Cells/cytology,metabolism Peritoneal Cavity/cytology Pulmonary Artery/physiopathology Pulmonary Circulation Rats Vascular Resistance

Chemicals

Carbon Isotopes

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Haas F

Bergofsky E H

References (22)

22 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI107142

Published

1972-12-00

Pages

3154-62

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC332997

Subset

External Links

PubMed source DOI: 10.1172/JCI107142 PMC Full Text View journal details

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Role of the mast cell in the pulmonary pressor response to hypoxia.

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