Myelination inhibition factor: dissociation from induction of experimental allergic encephalomyelitis.

Science (New York, N.Y.) ·Vol. 179 ·No. 4074 ·1973-02-16 ·Pages 689-90

Kies MW, Driscoll BF, Seil FJ, Alvord EC

Abstract

Sensitization of guinea pigs with purified myelin basic protein induces experimental allergic encephalomyelitis (EAE) but does not induce a serum factor which inhibits myelin formation in vitro. This factor, induced by some unidentified constituent of whole central nervous system tissue, should not be characterized as a component of "EAE serum."

MeSH Terms

Animals Antibody Formation Antigen-Antibody Reactions Antigens Cerebellum/drug effects Culture Techniques Demyelinating Diseases/immunology Encephalomyelitis, Autoimmune, Experimental/immunology Guinea Pigs Immune Sera/pharmacology Iodine Isotopes Myelin Basic Protein Myelin Sheath/immunology Nerve Tissue Proteins Rabbits/immunology Spinal Cord/immunology

Chemicals

Antigens Immune Sera Iodine Isotopes Myelin Basic Protein Nerve Tissue Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Kies M W

Driscoll B F

Seil F J

Alvord E C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.179.4074.689

Published

1973-02-16

Pages

689-90

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.179.4074.689 View journal details

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Myelination inhibition factor: dissociation from induction of experimental allergic encephalomyelitis.

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