Endogenous inhibitor of prostaglandin synthetase.

Nature ·Vol. 270 ·No. 5632 ·1977-11-03 ·Pages 32-6

Saeed SA, McDonald-Gibson WJ, Cuthbert J, Copas JL, Schneider C, Gardiner PJ, Butt NM, Collier HO

Abstract

Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.

MeSH Terms

Adrenal Cortex Hormones/pharmacology Airway Resistance/drug effects Animals Arachidonic Acids/antagonists & inhibitors Arthritis, Experimental/enzymology Biological Assay Cattle Cyclooxygenase Inhibitors Enzyme Inhibitors/blood Humans Male Prostaglandins E/biosynthesis Prostaglandins F/biosynthesis Seminal Vesicles/enzymology

Chemicals

Adrenal Cortex Hormones Arachidonic Acids Cyclooxygenase Inhibitors Enzyme Inhibitors Prostaglandins E Prostaglandins F

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Saeed S A

McDonald-Gibson W J

Cuthbert J

Copas J L

Schneider C

Gardiner P J

Butt N M

Collier H O

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/270032a0

Published

1977-11-03

Pages

32-6

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/270032a0 View journal details

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