Hapten-specific stimulation of secondary B cells independent of T cells.
Treatment of spleen cell suspensions from immunized mice with anti-theta serum and complement before transfer to nonimmune irradiated recipients reduced the degree of in vitro stimulation by hapten-homologous carrier complexes by 90%, but did not decrease at all the number of isolated precursor cells stimulated by hapten on heterologous carriers. Thus, secondary B cells can be stimulated by low concentrations of multiply substituted hapten-carrier complexes in the apparent complete absence of specific T cells.
17 references, click to expand
-
The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis.Eur J Immunol. 1971 Jan;1(1):10-7 PMID: 14978856
-
STUDIES ON DELAYED HYPERSENSITIVITY. I. INFERENCES ON THE COMPARATIVE BINDING AFFINITIES OF ANTIBODIES MEDIATING DELAYED AND IMMEDIATE HYPERSENSITIVITY REACTIONS IN THE GUINEA PIG.J Exp Med. 1965 Jun 1;121:873-88 PMID: 14319404
-
Antigenicity of polypeptides (poly-alpha-amino acids). XXVI. Studies of the ability of homo- and copolymers to act as hapten carriers in mice.J Immunol. 1968 Feb;100(2):384-94 PMID: 5639704
-
Heterologous carriers in the anamnestic antihapten response.J Exp Med. 1968 Apr 1;127(4):717-30 PMID: 4171054
-
The secondary immune response to a hapten in vitro. Antigen concentration and the carrier effect.J Exp Med. 1971 May 1;133(5):963-72 PMID: 4101805
-
The stimulation of splenic foci in vitro.J Immunol. 1971 May;106(5):1338-44 PMID: 4102405
-
The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response.J Exp Med. 1971 Jul 1;134(1):103-19 PMID: 4104294
-
Interaction between lymphocytes in immune responses.Cell Immunol. 1971 Oct;2(5):469-95 PMID: 4399419
-
The mechanism of antigenic stimulation of primary and secondary clonal precursor cells.J Exp Med. 1972 Aug 1;136(2):241-60 PMID: 4114497
-
Antigen recognition and the immune response. "Self-help" with symmetrical bifunctional antigen molecules.J Exp Med. 1972 Dec 1;136(6):1478-83 PMID: 4118413
-
Immunologic reactions to haptens on autologous carriers. I. Participation of both thymus-derived and bone marrow-derived cells in the secondary in vitro response.J Exp Med. 1973 Feb 1;137(2):411-23 PMID: 4119590
-
Factors affecting the propagation of a B cell clone forming antibody to the 2,4-dinitrophenyl group.Eur J Immunol. 1972 Dec;2(6):487-93 PMID: 4120275
-
Studies on immunological paralysis. VI. Thymic-independence of tolerance and immunity to type 3 pneumococcal polysaccharide.Cell Immunol. 1971 Dec;2(6):614-26 PMID: 4149977
-
IMMUNOLOGICAL SPECIFICITY OF THE SECONDARY RESPONSE WITH DINITROPHENYLATED PROTEINS.Proc Soc Exp Biol Med. 1963 Oct;114:72-6 PMID: 14076917
-
THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.J Exp Med. 1964 Sep 1;120:413-33 PMID: 14207060
-
QUANTITATIVE TITRATIONS OF MOUSE H-2 ANTIBODIES USING CR-51-LABELLED TARGET CELLS.Transplantation. 1965 May;3:423-31 PMID: 14285093
-
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.Eur J Immunol. 1971 Jan;1(1):18-27 PMID: 14978857
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
